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Chlorprothixene pills 50mg №30
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/ Chlorprothixene
Active ingredient and dosage form
Chlorprothixene - coated tablets:
1 tab. contains chlorprothixene hydrochloride 15 and 50 mg, excipients: corn starch, lactose monohydrate, sucrose, Calcium stearate, talc;
in packs of 30 pcs.
Mechanism of action
The antipsychotic effect of Chlorprothixene is associated with its blocking effect on dopamine receptors. The blocking of these receptors is also associated antiemetic and analgesic properties of the drug. Chlorprothixene is able to block 5-HT2 receptors, α1 -adrenoreceptors, and H1-histamine receptors, which determines its adreno-blocking hypotensive and antihistamine properties.
Indications and usage
Chlorprothixene is a sedative neuroleptic with a wide range of indications, which include:
- psychosis, including schizophrenia and manic states, occurring with psychomotor agitation, agitation and anxiety;
- "hangover" withdrawal syndrome in alcoholism and drug addiction;
- hyperactivity, irritability, agitation, confusion in elderly patients;
- behavioral disorders in children;
- depression, neurosis, psychosomatic disorders;
- insomnia;
- pain (in combination with analgesics).
Contraindications
- depression of the central nervous system of any origin (including that caused by alcohol, barbiturates or opiates);
- coma;
- vascular collapse;
- diseases of the blood;
- pheochromocytoma;
- Hypersensitivity to the components of Chlorprothixene.
during pregnancy and breastfeeding
If possible, Chlorprothixene should not be given to pregnant women during breastfeeding.
Adverse reactions
Drowsiness, tachycardia, dry mouth, excessive sweating, difficulty of accommodation. These side effects, usually occurring at the beginning of therapy, often disappear as it continues.
Orthostatic hypotension may occur, especially when Chlorprothixene is used in high dosages.
Dizziness, dysmenorrhea, skin rashes, constipation are rare. Extrapyramidal symptoms are especially rare.
Described isolated cases of decrease in seizure threshold, the occurrence of transient benign leukopenia and hemolytic anemia.
With prolonged use, especially in high doses, there may be: cholestatic jaundice, galactorrhea, gynecomastia, decrease in potency and / or libido, increased appetite, increase in body weight.
Dosage and administration
Chlorprothixene take inside. Dose, frequency and duration of use are set individually. The average daily dose, divided into 2-3 doses, is 500 mg.
Storage conditions
In the dark place at a temperature of no higher than 25 ° C. Shelf life - 2 years.