Glencet pills 5mg №10

Coated tablets

Composition

In 1 tablet, film coated contains:

- Active substance
- Levocetirizine dihydrochloride 5 mg.

- Auxiliary substances Lactose monohydrate (Tabletoses 100), microcrystalline cellulose (Avicel PH 112), colloidal silicon dioxide (Aerosil 200), Magnesium stearate, opadry white.

Packaging

In the blister of 10 tablets. In a pack of cardboard 1 blister.

Mechanism of action

Glencet - Cetirizine enantiomer, a competitive histamine antagonist, blocks the H1-histamine receptors, the affinity for which is 2 times higher than that of cetirizine. It affects the histamine-dependent stage of allergic reactions, reduces the migration of eosinophils, vascular permeability, limits the release of inflammatory mediators. It prevents the development and facilitates the course of allergic reactions, has anti-exudative, antipruritic effect, practically does not have anticholinergic and antiserotonin action. In therapeutic doses, the sedative effect is very weak. The action begins 12 minutes after administration of a single dose in 50% of patients, after 1 h in 95% and lasts for 24 hours.

Indications and usage

- Symptomatic treatment of urticaria, including:
- Chronic idiopathic urticaria.
- Swelling Quincke.

Contraindications

- Hypersensitivity (including to piperazine derivatives).
- Severe chronic renal failure (CRF, CC less than 10 ml / min).
- Pregnancy.
- Lactation period.
- Children's age up to 6 years.
- Galactose intolerance, lactase deficiency and glucose-galactose malabsorption.

- Chronic renal failure (requires dosing regimen adjustment).
- Older age (possibly reduced glomerular filtration).

Dosage and administration

To accept inside, during food or on an empty stomach, washing down with a small amount of water, not chewing.

The recommended dose for adults and children over 6 years old, elderly patients (assuming normal kidney function) is 5 mg (1 tablet) 1 time per day.

The course of treatment for chronic diseases is up to 18 months.

- Use in special clinical situations In patients with chronic renal insufficiency, the dose is halved (1 pill every other day) with QC from 30 to 49 ml / min and 3 times (1 pill in 3 days) with QC from 10 to 29 ml / min Patients with liver failure do not need to adjust the dosage regimen.

Possible side effects are listed below for body systems and frequency of occurrence:

- Often (? 1/10).
- Infrequently (? 1/100,