Vitamin E capsules 100mg №20

Latin name

VITAMIN E

Release form

Red capsules, oval; the contents of the capsules are clear, light yellow colored oil.

Packaging

10 pieces. - blister packs (2) - cardboard packs.

Mechanism of action

Vitamin has an antioxidant effect, is involved in the biosynthesis of heme and proteins, cell proliferation, tissue respiration and other important processes of tissue metabolism, prevents hemolysis of red blood cells, reduces the increased permeability and capillary fragility. It is necessary for the development and functioning of connective tissue, smooth and skeletal muscles, as well as for strengthening the walls of blood vessels. Takes part in the metabolism of nucleic acids and prostaglandins, the cellular respiratory cycle, in the synthesis of arachidonic acid.

It is a natural antioxidant, inhibits lipid peroxidation by free radicals. It activates phagocytosis and is used to maintain the normal resistance of red blood cells. In large doses, it prevents platelet aggregation.
It has a pronounced positive effect on the human reproductive system, slows down the development of atherosclerotic vascular changes.

Indications

• prevention and treatment of vitamin E hypovitaminosis;
• in the treatment of hormonal treatment of menstrual disorders, degenerative and proliferative changes of the joints and ligaments, spine, muscular dystrophy, and amyotrophic lateral sclerosis;
• state of convalescence after illness;
• poor and unbalanced nutrition;
• increased exercise.

Contraindications

• acute myocardial infarction;
• childhood;
• hypersensitivity to the drug components

With caution used in patients with severe cardiosclerosis, myocardial infarction, with an increased risk of thromboembolism; hypoprothrombinemia caused by vitamin K deficiency may worsen when using vitamin E in a dose of more than 400 IU.

Use during pregnancy and lactation

During pregnancy and breastfeeding, taking the drug only on the recommendation of a doctor

Composition

Auxiliary substances: sunflower oil - 100 mg.

The composition of the capsule shell: gelatin - 44.73 mg, glycerol - 14.67 mg, methyl para-hydroxybenzoate - 0.29 mg, dye azorubine - 0.31 mg.

Dosage and administration

Adults: 100 mg capsules - 2-4 caps / day; 200 mg capsules - 1-2 capsules / day; 400 mg capsules - 1 capsule / day.
For violations of the menstrual cycle (as a supplement to hormone therapy) 300-400 mg every other day, sequentially, starting from the 17th day of the cycle.

Side effects

Possible: allergic reactions.
On the part of the digestive system: diarrhea, nausea, gastralgia.
Rarely, in patients with predisposition, creatinuria, an increase in the activity of creatine kinase, an increase in serum cholesterol level, thrombophlebitis, pulmonary thromboembolism, and thrombosis occur.

Drug interaction

Enhances the effect of GCS, NSAIDs, cardiac glycosides. Increases the effectiveness of antiepileptic drugs in patients with epilepsy (in which the content of lipid peroxidation products in the blood is increased).
Iron increases the daily need for vitamin E.
Vitamin E enhances the effect of anticoagulants, if the doses exceed 400 ME / day.
It is not recommended to take other vitamin complexes containing vitamin E at the same time in order to avoid overdosing.
Prescribing high doses of vitamin E can cause a vitamin A deficiency in the body.
The simultaneous use of vitamin E in a dose of more than 400 IU per day with anticoagulants (coumarin and indandion derivatives) increases the risk of developing hypothrombinemia and bleeding.
Kolestiramin, Kolestipol, mineral oils reduce absorption.

Overdosage

High doses of vitamin E (400-800 mg / day for a long time) can cause visual impairment, diarrhea, dizziness, headache, nausea, fatigue, fainting, white hair growth in areas of alopecia with vesicular epidermolysis.
Very high doses (exceeding 800 mg for a long time) can causebleeding in patients with vitamin K deficiency; they can disrupt the metabolism of thyroid hormones and increase the risk of thrombophlebitis and thromboembolism in sensitive patients.