Quentiax Wed pills 300mg №60

Pharmacological group

Antipsychotic drug (neuroleptic)

Indications

- treatment of acute and chronic psychosis, including schizophrenia;

- treatment of manic episodes in bipolar disorder.

Contraindications

- breastfeeding period;

- children and adolescents under 18 years of age (efficacy and safety have not been established);

- Hypersensitivity to Quetiapine or other components of the drug.

WITH caution the drug should be prescribed to patients with cardiovascular and cerebrovascular diseases or other conditions predisposing to arterial hypotension, with a congenital increase in the QT interval on an electrocardiogram or in the presence of conditions potentially capable of increasing the QT interval, hypomagnesemia), with liver failure, epilepsy, convulsive seizures in history, pregnancy, elderly patients.

Side effects

Classification of the incidence of side effects (WHO): very often (> 1/10), often (> 1/100, <1/10), infrequently (> 1/1000, <1/100), rarely (> 1/10 000, <1/1000), very rarely (<1/10 000, including individual messages).

Hemic and lymphatic: often - leukopenia; infrequently - eosinophilia; very rarely - neutropenia.

From the central and peripheral nervous system: very often - dizziness, drowsiness, headache; often - syncopal states; infrequently - anxiety, agitation, insomnia, akathisia, tremor, convulsions, depression, paresthesias; rarely - neuroleptic malignant syndrome (hyperthermia, impaired consciousness, muscle rigidity, vegetative-vascular disorders, increased concentration of CPK); very rarely - tardive dyskinesia.

Since the cardiovascular system: often - tachycardia, orthostatic hypotension, prolongation of the QT interval on the ECG.

Respiratory: rhinitis, pharyngitis.

Gastrointestinal: often - dry mouth, constipation, diarrhea, dyspepsia, increased levels of serum transaminases (ACT or ALT); rarely - jaundice, nausea, vomiting, abdominal pain; very rarely - hepatitis.

Allergic reactions: infrequently - skin rash, hypersensitivity reactions; very rarely - angioedema, Stevens-Johnson syndrome.

From the reproductive system: rarely priapism.

On the part of the endocrine system: often - weight gain (mainly in the first weeks of treatment); very rarely - hyperglycemia or decompensation of diabetes.

Laboratory values: infrequently - an increase in the serum level of GGT and the content of triglycerides (not fasting), hypercholesterolemia; decrease in the level of thyroid hormones (total T4 and free T4 / in the first 4 weeks /, as well as total T3 and reverse T3 / only when taking high doses of quetiapine /).

Other: often - peripheral edema, asthenia; rarely - back pain, chest pain, low-grade fever, myalgia, dry skin, impaired vision.

Mode of application

The drug is administered orally, 2 times / day, regardless of the meal.

At treatment of acute and chronic psychosis, including schizophrenia, the daily dose in the first 4 days is: 1st day - 50 mg; 2nd day - 200 mg; 3rd day - 200 mg and 4th day - 300 mg. Starting from the 4th day, the daily dose is 300 mg. Depending on the clinical effect and tolerability of the drug, its dose may individually vary from 150 mg / day to 750 mg / day. The maximum daily dose for the treatment of schizophrenia is 750 mg.

At treatment of manic episodes in bipolar disorder Quetiapine is recommended as monotherapy or as an adjuvant therapy to stabilize mood.

The daily dose in the first 4 days is: 1st day - 100 mg; 2nd day - 200 mg; 3rd day - 300 mg and 4th day - 400 mg. An increase in the daily dose in the future is possible at 200 mg / day and by day 6 of therapy is 800 mg. Depending on the clinical effect and tolerability of the drug, its dose may individually vary from 200 mg / day to 800 mg / day. As a rule, the effective dose ranges from 400 mg to 800 mg / day. The maximum daily dose is 800 mg.

Since plasma clearance of quetiapine elderly patients reduced by 30-50%, should be prescribed with caution, especially at the beginning of therapy. The starting dose is 25 mg / day, followed by an increase of 25-50 mg to achieve an effective dose.

Have patients with renal and hepatic insufficiency It is recommended to begin therapy with 25 mg / day. In the future, it is recommended to increase the dose daily by 25-50 mg to achieve an effective dose.

Pharmacy holidays