Claritin pills 10mg №10

Active ingredient and dosage form

Pills white or almost white oval, on one side of which there is a risk, as well as the trademark "Cup and flask" and the number "10". On the other hand, the pill has the usual appearance.
1 pill contains loratadine 10 mg;
Excipients: corn starch, lactose, Magnesium stearate.
in a blister, 10 pcs., 1 or 3 blisters in a carton box, or
in the blister is 7 pieces, 1 blister in a cardboard pack.

Syrup clear, colorless or slightly yellowish syrup that does not contain foreign substances.
5 ml of syrup contain loratadine 5 mg;
Excipients: citric acid, artificial flavor (peach), glycerin, propylene glycol, sodium benzoate, granulated sucrose, water (pH 2.5–3.1);
in dark glass bottles of 60 or 120 ml, 1 bottle complete with a measuring spoon in a cardboard bundle.

tab. 10 mg: - P No. 013494/01-2001, 19.11.01
syrup 5 mg / 5 ml: - P No. 013494/02-2001, 19.11.01

Mechanism of action

Histamine H blocker₁-receptor is a tricyclic compound. Characterized by selective antagonism with respect to peripheral receptors of the specified type.
When conducting skin tests on histamine after administration of one (10 mg) or several doses of Claritin, the antihistamine effect manifested itself within 1-3 hours, reached a maximum between 8 and 12 hours from the onset of action and lasted more than 24 hours.
When receiving Claritin for 28 days there was no development of resistance to the drug.
When conducting a clinical study in which Claritin was used for 90 days at a dose exceeding the therapeutic one 4 times, there was no clinically significant prolongation of the QT interval on the ECG.

Indications and usage

- treatment of seasonal and year-round allergic rhinitis and elimination of symptoms associated with these diseases: sneezing, itching of the nasal mucosa, rhinorrhea, burning sensation and itching in the eyes;
- treatment of skin diseases of allergic origin (including chronic urticaria) in adults and children from the age of 2 years.

Dosage and administration

For adults, elderly patients and children over 12 years old The recommended dose of Claritin is 10 mg - 1 tab. or 2 teaspoons (10 ml) of syrup 1 time / day.
For children aged 2 to 12 years (with body weight less than 30 kg) The recommended dose of Claritin is 5 mg - 1 tsp (5 ml) of syrup or 1/2 tab. 1 time / day; with a body weight of 30 kg or more - 10 mg - 2 teaspoons (10 ml) of syrup or 1 tab. 1 time / day
For patients with impaired liver function or renal failure (CC less than 30 ml / min) the initial dose of the drug is 10 mg - 1 tab. or 2 teaspoons (10 ml) of syrup every other day.

Adverse reactions

From the digestive system in adults: possible - dry mouth, nausea, gastritis; rarely - liver dysfunction.
From the side of the central nervous system in adults: perhaps - headache, fatigue, drowsiness; in children (rarely) - headache, nervousness, sedative effect.
Allergic reactions in adults: possible skin rash; rarely - Anaphylactic reactions.
Dermatological reactions in adults: there were rare reports of alopecia.
The incidence of these side effects with Claritin was the same as with placebo.

Contraindications

- lactation period (breastfeeding);
- Hypersensitivity to loratadine or other components of the drug.
Carefully should use the drug during pregnancy.

Pregnancy and breastfeeding

Use of the drug during pregnancy is possible only in cases of extreme necessity.
AT experimental studies no teratogenic effect of loratadine was detected in animals.
Loratadine and its metabolite descarboethoxyloratadine easily penetrate into breast milk, where they reach concentrations close to their plasma concentrations. Therefore, if necessary, use of the drug during lactation should stop breastfeeding.

Special notes

Reception of Claritin should be stopped no later than 48 hours prior to skin tests, in order to avoid distortion of the results.
In the study of psychomotor function after applying Claritin simultaneously with alcohol, the potentiating effect of Claritin on alcohol was not revealed.
Use in pediatrics
Do not use the drug in children under 2 years old.

Overdosage

Symptoms: in adult patients, headache, drowsiness and tachycardia were observed when taking the drug in doses of 40-180 mg, far exceeding the recommended therapeutic dose of 10 mg.In children weighing less than 30 kg, extrapyramidal symptoms and palpitations were noted when taking Claritin syrup at a dose of more than 10 mg.
Treatment: conducting symptomatic and supportive therapy. Loratadine is not excreted through hemodialysis. Data on the elimination of loratadine during peritoneal dialysis is not available.

Drug Interactions

With the simultaneous use of Claritin with Ketoconazole, Erythromycin or cimetidine, there was an increase in the concentration of loratadine and its metabolite in the blood plasma, which was not manifested clinically (including ECG data).

Storage conditions

The drug should be stored at a temperature of 2 ° to 30 ° C.