Baclofen/baclosan/pills 25mg №50

Dosage form

Pills

Composition

1 pill contains 25 mg of Baclofen.

50 pcs.

Mechanism of action

Baklosan - centrally acting muscle relaxant; GABAB receptor agonist. Reducing the excitability of the terminal parts of afferent sensory fibers and suppressing intermediate neurons, inhibits the mono-and polysynaptic transmission of nerve impulses; reduces prestressing muscle spindles. Baklosan does not affect the transmission of impulses in the neuromuscular synapses. In neurological diseases accompanied by skeletal muscle spasticity, it relieves painful spasms and clonic convulsions. Increases the amount of movement in the joints, facilitates the holding of passive and active kinesitherapy (exercise, massage, manual therapy).

Indications and usage

Increase muscle tone:
- With multiple sclerosis;
- in diseases of the spinal cord of infectious, degenerative and traumatic genesis (for example, tumor, syringomyelia, motor neuron disease, trauma);
- with a stroke;
- with cerebral palsy;
- with meningitis;
- with traumatic brain injuries;
- in alcoholism (affective disorders).

Contraindications

- psychosis;
- Parkinson's disease;
- epilepsy;
- convulsions (in history);
- chronic renal failure;
- pregnancy;
- lactation (breastfeeding);
- hypersensitivity to baclofen.

Dosage and administration

Adults Baklosan prescribed in the initial dose of 5 mg 3 times a day; gradually, every 3 days, increase the dose until the development of the optimal therapeutic effect (usually up to 30-75 mg / day). Patients who require the use of Buklosan in higher doses (usually up to 30-75 mg / day), Buklosan prescribed in pills of 25 mg. The maximum daily dose is 100 mg.

Adverse reactions

On the part of the central nervous system and peripheral nervous system: drowsiness, dizziness, gait disturbance, fatigue, confusion, apathy, euphoria, depression, paresthesia, ataxia, tremor, nystagmus, accommodation pallus, hallucinations, convulsions, decrease in seizure threshold.
On the part of the digestive system: nausea, vomiting, dry mouth, constipation, diarrhea.
On the part of the urinary system: urinary retention, dysuria, enuresis; with prolonged use - impaired renal function.
Since the cardiovascular system: a decrease in blood pressure.
Other: myalgia, muscle weakness.

In patients with diseases of the liver and diabetes mellitus, it is necessary to periodically monitor the activity of hepatic transaminases and alkaline phosphatase, as well as blood glucose.

Drug interactions

With the simultaneous use of Baklosan enhances the effect of drugs that affect the central nervous system, antihypertensive drugs, ethanol. With simultaneous use of Baklosan with tricyclic antidepressants, a significant decrease in muscle tone is possible. In patients with Parkinson's disease, while taking Baklosan with levodopa and carbidopa, hallucinations, confusion, agitation can occur.

Overdosage

Symptoms: hypotonia, depression of the respiratory center, confusion, coma (after regaining consciousness, hypotension can persist for 72 hours).
Treatment: heavy drinking, diuretic intake, respiratory depression - mechanical ventilation. There is no specific antidote.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C.

5 years.