Metformin pills 850mg №60

Mechanism of action

Metformin

Indications and usage

Type 2 diabetes mellitus (especially in cases involving obesity) with the ineffectiveness of the correction of hyperglycemia by diet therapy, including in combination with sulfonylureas.

Contraindications

Hypersensitivity, kidney disease or renal insufficiency (the level of creatinine is more than 0.132 mmol / l in men and 0.123 mmol / l in women), marked impairment of liver function; conditions accompanied by hypoxia (including cardiac and respiratory failure, acute phase of myocardial infarction, acute cerebrovascular insufficiency, anemia); dehydration, infectious diseases, extensive surgeries and injuries, chronic alcoholism, acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without a coma, history of lactic acidosis, adherence to a low-calorie diet (less than 1000 kcal / day), conducting studies using radioactive Iodine isotopes, pregnancy, breastfeeding.

Adverse reactions

On the part of the gastrointestinal tract: at the beginning of the course of treatment - anorexia, diarrhea, nausea, vomiting, flatulence, abdominal pain (reduced when taken during meals); metallic taste in the mouth (3%).

Since the cardiovascular system and blood (hematopoiesis, hemostasis): in rare cases - megaloblastic anemia (the result of a violation of the absorption of vitamin B12 and folic acid).

Metabolism: hypoglycemia; in rare cases - lactic acidosis (weakness, drowsiness, hypotension, resistant bradyarrhythmia, respiratory disorders, abdominal pain, myalgia, hypothermia).

For the skin: rash, dermatitis.

Dosage and administration

Metformin is taken orally. pills should be taken whole, during or immediately after a meal, washed down with a small amount of liquid (a glass of water). To reduce side effects from the gastrointestinal tract, the daily dose should be divided into 2-3 doses.

The dose of Metformin is determined by the doctor individually, depending on the level of glucose in the blood.

Tablets 0.5 g: initial dose - 0.5-1 g / day. After 10-15 days, a further gradual increase in dose is possible depending on the level of glucose in the blood. Maintenance dose is usually 1.5-2 g / day. The maximum dose - 3 g / day.

Tablets 0.85 g: the initial dose - 0.85 g / day. After 10-15 days, a further gradual increase in dose is possible depending on the level of glucose in the blood. Maintenance dose is usually 1.7 g / day. The maximum dose is 2.55 g / day. In elderly patients, the recommended daily dose should not exceed 0.85-1 g.

Storage conditions

In the dark place at a temperature of no higher than 20 ° C.