Buy Valparin XP tablets prolonged 300mg №100
  • Buy Valparin XP tablets prolonged 300mg №100

Valparin XP pills prolonged 300mg №100

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Coated Extended Release Tablets

Composition

1 tab. contains sodium valproate 200 mg, valproic acid 87 mg, which corresponds to the total sodium content of valproate 300 mg

Packing

100 pieces.

Mechanism of action

Valparin XP is an anticonvulsant drug. Sodium valproate increases the content of gamma aminobutyric acid (GABA) in the brain, which accordingly increases the content of GABA in postsynaptic neurons. In addition, sodium valproate affects the transfer of potassium ions through the membranes of neurons. As a result, the development and spread of epileptic excitation along neurons are suppressed.
Sodium valproate has anticonvulsant activity in various types of epilepsy in humans. Valparin XP does not have a pronounced hypnotic and sedative effects, and also has no inhibitory effect on the respiratory center. Sodium valproate does not have a negative effect on blood pressure, heart rate, kidney function and body temperature.

Indications and usage

Treatment of generalized or partial epilepsy, especially for the following types of seizures:
- absences;
- myoclonic;
- tonic-clonic;
- atonic.
Partial epilepsy:
- simple or combined seizures;
- secondary generalized seizures.
Specific syndromes (Vesta, Lennox-Gasto).

Contraindications

- severe dysfunction of the pancreas;
- acute or chronic hepatitis, cases of active hepatitis in the family history (primarily of medicinal genesis);
- porphyria;
- thrombocytopenia;
- pregnancy;
- lactation (breastfeeding);
- children's age up to 3 years;
- Hypersensitivity to valproic acid and other components of Valparin XP.

Dosage and Administration

The drug should be taken orally, without chewing, washing down with a small amount of water. Dosing regimen Valparin XP is selected individually depending on age and body weight. Adults: initial dose - 600 mg / day; then the dose is increased by 200 mg every 3 days until the optimum effect is achieved. Take 1-2 times a day. The maximum recommended dose is 1–2 g.

Adverse reactions

On the part of the digestive system: rarely - nausea, vomiting, diarrhea and / or constipation, hepatitis, pancreatitis.
Allergic reactions: rarely - skin rash, itching, photosensitivity, erythema multiforme, Stevens-Johnson syndrome.
From the side of the central nervous system: rarely - ataxia, tremor, impaired consciousness, coma.
On the part of the reproductive system: rarely - violation of the menstrual cycle, secondary amenorrhea.
On the part of the hematopoietic system: rarely - anemia, thrombocytopenia, neutropenia, leukopenia, a decrease in the content of fibrinogen, inhibition of platelet aggregation.

Special notes

Regular monitoring of transaminase activity, the content of bilirubin, blood platelets, amylase (every 3 months) is necessary.

Drug Interactions

The effect is reinforced by other anticonvulsants, sedatives and sleeping pills. Dyspeptic disorders develop less frequently on the background of antispasmodics and coating agents. Alcohol and other hepatotoxic drugs increase the likelihood of liver damage, and anticoagulants or Acetylsalicylic acid increase the risk of bleeding.

Storage conditions

In a dry, dark place at a temperature of no higher than 20 ° C.