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Latran pills 4mg №10
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Coated Tablets
Composition
1 tab. contains ondansetron hydrochloride dihydrate (in terms of base) 4 mg; excipients: MCC; colloidal silicon dioxide (aerosil); potato starch; Magnesium stearate; shell composition: hydroxypropylcellulose; twin 80 (polysorbate); tropeolin O; castor oil
Packing
10 pieces.
Mechanism of action
Latran has an antiemetic, anti-abstinent effect.
Indications and usage
- Nausea and vomiting caused by X-ray, radio, or Chemotherapy with anticancer drugs or exposure to ionizing radiation;
- prevention, prevention and elimination of nausea and vomiting in the postoperative period;
- symptomatic treatment of alcohol withdrawal syndrome (especially mild and moderate severity).
Contraindications
- Hypersensitivity to any component of Latran;
- pregnancy;
- breast-feeding;
- children's age up to 2 years (safety and efficacy in Russia has not been studied).
Dosage and administration
Cytostatic therapy: the choice of dosing regimen is determined by the emethogenicity of antitumor therapy. For adults, the daily dose is usually 8-32 mg, the following regimens are recommended:
With moderate emetogenic chemo or radiotherapy
- 8 mg orally (2 tablets) for 1-2 hours before the start of therapy, then another 8 mg (2 tablets) 12 hours after the start of therapy.
To prevent delayed vomiting that occurs after the first 24 hours from the start of chemotherapy, it is recommended to continue taking the drug orally in the form of tablets, 8 mg 2 times a day for 5 days.
Children older than 2 years: after the end of chemotherapy, it is recommended to continue treatment at a dose of 4 mg orally 2 times a day for 5 days.
Prevention of postoperative nausea and vomiting: Adults are given a single dose of 8 mg IM or IV slowly or slowly at the onset of anesthesia, or 16 mg should be administered orally 1 hour before the onset of anesthesia. For the relief of nausea and vomiting, it is recommended intramuscularly or slow i / v administration of 8 mg of the drug. V / m in the same area of the body Latran can be administered in a dose not exceeding 8 mg.
When exposed to ionizing radiation, Latran is taken orally in a single dose of 8 mg (2 tab.) 1 hour before or immediately after radiation exposure.
Adverse reactions
Nervous system disorders: headache, dizziness, spontaneous movement disorders and convulsions.
Cardiovascular: pain in the chest, in some cases with depression of the ST segment, bradycardia, arrhythmias, arterial hypotension.
On the part of the digestive tract organs: hiccups, dry mouth, diarrhea, constipation, and sometimes asymptomatic transient increases in serum aminotransferase levels.
Allergic reactions: urticaria, bronchospasm, laryngism, angioedema, anaphylaxis.
Other: local reactions (pain, burning and redness at the injection site), blood rush to the face, feeling hot, temporary visual acuity, hypokalemia.
In the dark place at a temperature of no higher than 25 ° C.