Flucinar n ointment 15g

Ointment for external use

Active ingredient

1 g of ointment for external use contains: fluocinolone acetonide 250 μg, neomycin 5 mg.
Excipients: propylene glycol, liquid paraffin, anhydrous lanolin, white petrolatum.

Packing

In a tub of aluminum 15 g ointment. In the package 1 tube.

Mechanism of action

Flucinar N - the combined drug with anti-inflammatory and antibacterial action.
Fluocinolone acetonide is a synthetic GCS for external use. 40 times more active than Hydrocortisone. It has anti-inflammatory, antipruritic, antiexudative, antiallergic and vasoconstrictor action. The mechanism of anti-inflammatory action is not fully understood. Fluocinolone acetonide is believed to reduce the manifestations of the inflammatory process, inhibiting the synthesis of prostaglandins and leukotrienes by inhibiting the activity of phospholipase A2 and reducing the release of arachidonic acid from the phospholipids of the cell membrane. As a result, hyperemia and exudation in the lesion are reduced.
Stabilizes cellular and subcellular (including lysosomal) membranes. Reduces the release of proteolytic enzymes from lysosomes. Reduces membrane permeability, mitotic activity and release of inflammatory mediators.When exposed to the skin, a warning of the marginal accumulation of neutrophils occurs, which leads to a decrease in inflammatory exudate and production of lymphokines, inhibition of macrophage migration, a decrease in infiltration and granulation processes. It inhibits the phase of alteration and limits the focus of inflammation, reduces the migration of leukocytes and lymphocytes to the focus of inflammation. It inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages. Reduces the severity of the early immune response.
Neomycin is an antibiotic of the aminoglycoside group. In low concentrations has a bacteriostatic effect, in high concentrations - bactericidal. The mechanism of action is associated with a direct effect on the ribosomes and the inhibition of bacterial cell protein synthesis.
Active against
- Gram-positive microorganisms: Staphylococcus spp., Streptococcus spp., Corynebacterium diphtheriae, Listeria monocytogenes, Bacillus antracis, Clostridium spp., Actinomyces spp., Neisseria meningitidis.
- Gram-negative microorganisms: Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Enterobacter aerogenes, Vibrio cholerae, Haemophilus influenzae, Klebsiella pneumoniae, Bordetella pertussis, Pasteurella multocida, Borrelia, click-now, in-click-now, click to apply, click to apply, and then apply to get help.
It is active against acid-resistant Mycobacterium tuberculosis. The resistance of microorganisms to neomycin develops slowly and to a small extent. As a result of the cumulative effect of fluocinolone acetonide and neomycin, the drug suppresses the development of inflammatory and allergic skin reactions, complicated by a bacterial infection.

Indications and usage

- Allergodermatosis, complicated by bacterial infection caused by neomycin-sensitive flora: allergic (incl.contact, professional, solar) dermatitis, eczema (including contact, constitutional, coin-like, seborrheic), urticaria, psoriasis (including the scalp), erythema multiforme, erythroderma, atopic dermatitis, pruritus; dermatosis that cannot be treated by other corticosteroids (including lichen planus, lupus erythematosus / skin manifestations /); secondary infections with insect bites.
- Bacterial infections of the skin caused by sensitive to neomycin flora, complicated by the development of allergic reactions: impetigo, infected diaper rash.
- Burns I degree.

Contraindications

- Bacterial (caused by neomycin-insensitive microorganisms) skin infections.
- Viral (herpes, chickenpox) infections of the skin.
- Fungal infections of the skin.
- Conditions after immunization.
- Skin manifestations of syphilis.
- Tuberculosis of the skin.
- Angular cheilitis.
- Perioral dermatitis.
- Chronic dermatosis of the face.
- Pink eels.
- Pregnancy.
- Lactation (breastfeeding).
- Children's age up to 2 years.
- Hypersensitivity to the drug.

Pregnancy and Breastfeeding

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Dosage and administration

Apply externally. A small amount of ointment is applied with a thin layer to the affected skin 2-3 times / day, then after subsiding the process - 1-2 times / day.If necessary, apply a breathable bandage. With excessive peeling (lichenisation) of the corneal layer of the epidermis or excessive keratinization of the modified areas, the ointment can be applied under an occlusive dressing, which should be changed every 24-48 hours. The course of treatment is no more than 2 weeks. Do not use more than 2 g of ointment per day. Children older than 2 years, the drug is prescribed 1 time / day. on limited areas of the skin in a short course.

Adverse reactions

Local reactions: very rarely - itching, irritation; sometimes the addition of a secondary infection caused by neomycin-resistant microorganisms; with long-term use on the skin of the face - steroid acne, telangiectasia, striae, skin atrophy, perioral dermatitis, depigmentation, alopecia, hirsutism; rarely - urticaria, maculo-papular rash.
Systemic side effects: with prolonged use or application to extensive surfaces, systemic side effects of corticosteroids may be developed, as well as oto- and nephrotoxic effects of neomycin.

It is not recommended to exceed the course of treatment, prolonged use over large areas of skin. If necessary, application of the drug on the skin of the face and skin folds treatment should be short. The drug should be used with caution in patients with atrophic skin changes, especially in elderly patients. With the development of a secondary infection in the place of use of the drug Flucinar H, it is necessary to prescribe drugs with a more pronounced antibacterial or antifungal effect. During treatment should not be vaccinated against smallpox.There should be no other types of immunization due to the immunosuppressive effect of corticosteroids.
Influence on ability to drive motor transport and control mechanisms: the use of the drug does not limit the psychophysical activity and ability to drive vehicles and work with mechanisms.

Drug interactions

With long-term use of the drug in large areas of the skin, especially with the use of occlusive dressings, fluocinolone, after absorption into the systemic circulation, may reduce the effectiveness of insulin, oral hypoglycemic drugs, antihypertensive drugs, anticoagulants; reduces the concentration of salicylates and praziquantel in serum. With simultaneous use of Flucinera H with androgens, estrogens, oral contraceptives, anabolic steroids increases the risk of developing hirsutism and acne. With simultaneous use of Flutsinara N with antipsychotics, bukarbanom, azathioprine increases the risk of developing cataracts. With simultaneous use of Flutsinara N with anticholinergics, antihistamines, tricyclic antidepressants, nitrates increases the risk of glaucoma. With simultaneous use of Flucinera H with diuretics increases the risk of hypokalemia. With simultaneous use of Flucinera H with cardiac glycosides increases the risk of digitalis intoxication.Prolonged use of Flucinera N simultaneously with Gentamicin, ethacrynic acid or colistin increases the risk of developing oto- and nephrotoxic action.

Overdosage

An overdose of Flucinara H when used topically is very rare.
Symptoms: with improper and long-term use of the drug on large areas of the skin, the systemic side effects of GCS, as well as oto- and nephrotoxic effects of neomycin, may develop.
Treatment: With the abolition of the drug overdose phenomena disappear independently.

At a temperature not higher than 25 ° С.