Buy Cerebrolysin ampoules 20ml No. 5
  • Buy Cerebrolysin ampoules 20ml No. 5

Cerebrolysin ampoules 20ml №5

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Nootropic agent

Mechanism of action

Nootropic drug.

Cerebrolysin® contains low molecular weight biologically active neuropeptides that penetrate the BBB and directly reach the nerve cells. The drug has an organ-specific multimodal effect on the brain, i.e. provides metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity.

Metabolic regulation: drug Cerebrolysin® improves the efficiency of the aerobic energy metabolism of the brain, improves intracellular protein synthesis in the developing and aging brain.

Neuroprotection: the drug protects neurons from the damaging effect of lactic acidosis, prevents the formation of free radicals, increases survival and prevents neuron death in conditions of hypoxia and ischemia, reduces the damaging neurotoxic effect of excitatory amino acids (glutamate).

Neurotrophic activity: drug Cerebrolysin® - the only nootropic peptidergic drug with proven neurotrophic activity, similar to the action of natural neuronal growth factors (NGF), but manifested under conditions of peripheral administration.

Functional neuromodulation: the drug has a positive effect on cognitive impairment on memory processes.

Pharmacokinetics

The complex composition of the drug Cerebrolysin®, the active fraction of which consists of a balanced and stable mixture of biologically active oligopeptides, which have a total multifunctional action, does not allow for the usual pharmacokinetic analysis of individual components.

Indications

- Alzheimer's disease;

- syndrome of dementia of various genesis;

- chronic cerebrovascular insufficiency;

- ischemic stroke;

- traumatic injuries of the brain and spinal cord;

- mental retardation in children;

- disorders associated with attention deficit in children;

- endogenous depression resistant to antidepressants (as part of complex therapy).

Dosage and administration

The drug is used parenterally. The dose and duration of use depend on the nature and severity of the disease, as well as on the age of the patient. Perhaps a single injection of the drug in a dose of up to 50 ml, but more preferably a course of treatment.

The recommended course of treatment is a daily injection for 10–20 days.

Indication

Dose

Acute conditions (ischemic stroke, traumatic brain injury, complications of neurosurgical operations)

from 10 ml to 50 ml

In the residual period of cerebral stroke and traumatic injury of the brain and spinal cord

from 5 ml to 50 ml

Psychoorganic syndrome and depression

from 5 ml to 30 ml

Alzheimer's disease, dementia of vascular and combined Alzheimer's vascular origin

from 5 ml to 30 ml

In neuropediatric practice

0.1-0.2 ml / kg body weight

To improve the effectiveness of treatment, repeated courses can be held as long as there is an improvement in the patient’s condition due to treatment. After the first course, the frequency of injections can be reduced to 2 or 3 times a week.

Cerebrolysin® used parenterally in the form of a / m injection (up to 5 ml) and / in injection (up to 10 ml). The drug in a dose of 10 ml to 50 ml is recommended to be administered only by means of slow intravenous infusions after dilution with standard solutions for infusions. The duration of infusions is from 15 to 60 minutes.

Side effect

The frequency of adverse reactions was determined in accordance with the WHO recommendations: very often: (≥1 / 10); often: (from ≥1 / 100 to <1/10); infrequently (from ≥1 / 1000 to <1/100); rarely (from ≥1 / 10,000 to <1/1000); very rarely, including individual posts (<1/10 000).

Immune system: very rarely - increased individual sensitivity, allergic reactions.

Psychological: rarely - the intended effect of activation is accompanied by agitation, manifesting aggressive behavior, confusion, insomnia.

Nervous system: rarely - too fast a drug can cause dizziness; very rarely - isolated cases of generalized epilepsy and one case of seizures was associated with Cerebrolysin.

Cardiovascular: very rarely - too fast a drug can lead to increased heart rate and arrhythmias.

Gastrointestinal: very rarely - dyspepsia, diarrhea, constipation, nausea, vomiting; rarely - loss of appetite.

Dermatological: very rarely - skin reactions; rarely, with an excessively rapid administration, a sensation of heat, sweating, and itching is possible.

Other: very rarely - redness, itching, burning at the injection site, pain in the neck, head and limbs, fever, slight back pain, shortness of breath, chills, collaptoid state.

According to the results of one study, a connection was reported between the use of the drug in rare cases (from> 1/10 000 to <1/1000) with hyperventilation, arterial hypertension, hypotension, fatigue, tremor, the possible development of depression, apathy and / or drowsiness, flu-like symptoms (cold, cough, respiratory tract infection).

Since Cerebrolysin® used mainly in elderly patients, the above symptoms of the disease are typical for this age group and often also occur without taking the drug.

It should be noted that some undesirable effects (agitation, arterial hypertension, arterial hypotension, lethargy, tremor, depression, apathy, dizziness, headache, shortness of breath, diarrhea, nausea) were detected during clinical studies and occurred equally in patients, receiving Cerebrolysin®and in placebo patients.

If any of the side effects indicated in the instructions are aggravated or any other side effects that are not indicated in the instructions are noted, the patient must inform the attending physician.

Notification in case of suspected side effects

It is important to report side effects after a drug is registered in order to ensure continuous monitoring of the risk / benefit ratio of the drug. Medical workers are asked to report all cases of side effects observed when using the drug through the national systems of reporting adverse reactions and / or at the representative office of the company.

Contraindications

- severe renal failure;

- epileptic status;

- Hypersensitivity to the drug.

WITH caution It should appoint a drug for allergic diathesis, epileptic diseases, including with generalized epilepsy, due to the possible increase in the frequency of attacks.

Use during pregnancy and lactation

During pregnancy and during breastfeeding Cerebrolysin® should be used only after a careful analysis of the ratio of the positive effect of treatment and the risk associated with its implementation.

results experimental studies give no reason to believe that Cerebrolysin® has any teratogenic effect or has a toxic effect on the fetus.However, similar clinical studies have not been conducted.

Application for violations of kidney function

Contraindicated in severe renal failure.

Special notes

If the injection is too fast, you may feel hot, sweating, dizziness. Therefore, the drug should be administered slowly.

Compatibility of the drug was tested and confirmed (within 24 hours at room temperature and the presence of light) with the following standard solutions for infusions: 0.9% sodium chloride solution, Ringer's solution, 5% dextrose (glucose) solution.

Allowed simultaneous use of the drug Cerebrolysin® with Vitamins and drugs that improve heart circulation, but these drugs should not be mixed in the same syringe with Cerebrolysin.

You should use only a clear solution of Cerebrolysin and only once.

Influence on ability to drive motor transport and control mechanisms

Clinical studies have shown that Cerebrolysin® It does not affect the ability to drive and use machinery.

Overdose

About cases of drug overdose Cerebrolysin® not reported.

Drug interaction

Given the pharmacological profile of the drug Cerebrolysin® special attention should be paid to possible additive effects when co-administered with antidepressants or MAO inhibitors . In such cases, it is recommended to reduce the dose of antidepressant. Use of the drug Cerebrolysin® in high doses (30-40 ml) in combination with MAO inhibitors in high doses can cause an increase in blood pressure.

Do not mix in the same infusion solution Cerebrolysin® and balanced solutions of amino acids.

Cerebrolysin® incompatible with solutions containing lipids, and with solutions that change the pH of the medium (5.0-8.0).

Terms and conditions of storage

The drug should be stored out of the reach of children, protected from light at a temperature not higher than 25 ° C. The shelf life of the drug in ampoules is 5 years, in bottles - 4 years. Do not use after the expiration date printed on the package.

Pharmacy sales terms

The drug is available on prescription.