Ranitidine pills 300mg №20

Active ingredient and dosage form

Coated tablets:
1 pill contains Ranitidine (in the form of hydrochloride) 150 or 300 mg;
10, 20, 30, 40, 50 pieces per pack.

Mechanism of action

Ranitidine is an antagonist of histamine H2-receptors of the parietal cells of the gastric mucosa. Reduces the basal and stimulated secretion of hydrochloric acid, caused by irritation of the baroreceptors, food load, the action of hormones and biogenic stimulants (gastrin, histamine, pentagastrin). Ranitidine reduces the volume of gastric juice and the content of hydrochloric acid in it, increases the pH of the stomach contents, which leads to a decrease in the activity of pepsin. After oral administration in therapeutic doses does not affect the level of prolactin. Inhibits microsomal enzymes. Duration of action after a single dose of up to 12 hours

Indications and usage

- prevention and treatment of gastric ulcer and / or duodenal ulcer;
- Zollinger-Ellison syndrome;
- symptomatic ulcers;
- prevention of stress ulcers in seriously ill patients;
- treatment and prevention of postoperative ulcers of the upper gastrointestinal tract;

Contraindications

- pregnancy;
- lactation (breastfeeding);
- children's age up to 14 years;
- Hypersensitivity to the drug.
Carefully - renal and / or liver failure, cirrhosis with portosystemic encephalopathy in history, acute porphyria (including in history).

Dosage and administration

Ranitidine is taken, regardless of the meal, without chewing, with a small amount of liquid.
Adults and children over 14 years.
With the exacerbation of gastric ulcer and / or duodenal ulcer the drug is prescribed 150 mg 2 times a day or 300 mg per night. If necessary, the daily dose of the drug can be increased to 450 mg.
For the prevention of gastric ulcer and / or duodenal ulcer prescribe 150 mg of the drug 1 time per day before bedtime.
With Zollinger-Ellison syndrome The initial dose of the drug is 150 mg 3 times a day. If necessary, the dose of the drug can be increased to 600-900 mg per day.
When postoperative ulcers occur Ranitidine is prescribed 150 mg 2 times a day. Healing usually occurs within 4 weeks.
For the prevention of stress ulcers in seriously ill patients the drug is prescribed 150 mg 2 times a day.

Adverse reactions

Seldom: headache, dizziness, fatigue, thrombocytopenia, allergic reactions in the form of skin rash.
Very rarely: hair loss.
With prolonged use of ranitidine in high doses, an increase in the content of prolactin, gynecomastia, amenorrhea are possible.

Special notes

With caution, the drug is prescribed to patients with severely impaired liver and / or kidney function.
Before starting to use the drug, it is necessary to exclude the possibility of the presence of a malignant disease of the esophagus, stomach, duodenum.
If it is necessary to stop treatment, the drug is canceled, gradually reducing the dose.
The effectiveness of prophylactic use of Ranitidine when taking the drug in courses for 45 days in the spring and autumn period is higher than when it is taken continuously.

Drug Interactions

In cases where the drug is used in combination with antacids, the interval between taking antacids and Ranitidine should be at least 1-2 hours (antacids can cause a violation of Ranitidine absorption).
The drug has virtually no effect on the activity of microsomal liver enzymes.
Smoking reduces the effectiveness of ranitidine.
Due to the increase in the pH of the contents of the stomach while taking it may decrease the absorption of itrakenazole and Ketoconazole.
Metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propranolol, diazepam, Lidocaine, phenytoin, theophylline, aminophylline, indirect anticoagulants, glipizide, buformin, Metronidazole, Calcium antagonists, inhibits.
Drugs that inhibit bone marrow, increase the risk of neutropenia.

In dry, the dark place at a temperature below 25 ° C

- 3 years.