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Cosmetic brands
Omeprazole Capsules 40mg №28
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Active substance
Omeprazole
Composition
1 capsule contains:
Active substance: Omeprazole 40 mg;
Excipients: gelatin; glycerol; nipagin; nipazol; sodium lauryl sulfate; titanium dioxide; purified water; the dye E 129.
pharmachologic effect
Omeprazole - proton pump inhibitor, anti-ulcer.
Indications
- peptic ulcer and duodenal ulcer;
- reflux esophagitis;
- erosive and ulcerative lesions of the stomach and duodenum associated with taking NSAIDs;
- stressful ulcers;
- erosive and ulcerative lesions of the stomach and duodenum associated with Helicobacter pylori (as part of complex therapy);
- Zollinger-Ellison syndrome.
Contraindications
- hypersensitivity to the drug;
- childhood;
- pregnancy;
- lactation period.
Side effects
On the part of the digestive system: diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disorders, stomatitis, transient elevation of plasma liver enzymes; in patients with previous severe liver disease - hepatitis (including jaundice), impaired liver function.
Nervous system: headache, dizziness, agitation, drowsiness, insomnia, paresthesias, depression, hallucinations; in patients with severe concomitant somatic diseases,in patients with previous severe liver disease, encephalopathy.
Musculoskeletal system: muscle weakness, myalgia, arthralgia.
Hemic and lymphatic: leukopenia, thrombocytopenia; in some cases - agranulocytosis, pancytopenia.
From the skin: itching; rarely (in some cases) photosensitivity, erythema multiforme, alopecia.
Allergic reactions: urticaria, angioedema, bronchospasm, interstitial nephritis and anaphylactic shock.
Other: blurred vision, peripheral edema, increased sweating, fever, gynecomastia; rarely - the formation of gastric glandular cysts during long-term treatment (a consequence of the inhibition of the secretion of hydrochloric acid, is benign reversible).
Interaction
Long-term use of omeprazole in a dose of 20 mg 1 time per day in combination with caffeine, theophylline, Piroxicam, Diclofenac, Naproxen, Metoprolol, propranolol, ethanol, cyclosporine, Lidocaine, quinidine and estradiol did not change their plasma concentration.
No interactions with concomitant antacids were observed.
Changes the bioavailability of any drug, the absorption of which depends on the pH value (for example, iron salts).
How to take, the course of administration and dosage
Inside washing it down with a small amount of water (the contents of the capsule cannot be chewed).
Duodenal ulcer in acute phase - 1 capsule (40 mg) per day for 2-4 weeks (in resistant cases - up to 2 capsules per day).
Peptic ulcer in the acute phase and erosive and ulcerative esophagitis - 1-2 capsules per day for 4-8 weeks.
Erosive and ulcerative lesions of the gastrointestinal tract caused by the intake of NSAIDs - 1 capsule per day for 4-8 weeks.
Eradication of Helicobacter pylori - 1 capsule 2 times a day for 7 days in combination with antibacterial agents.
Anti-relapse treatment of gastric ulcer and duodenal ulcer - 1 capsule per day.
Anti-relapse treatment of reflux esophagitis - 1 capsule per day for a long time (up to 6 months).
Zollinger-Ellison Syndrome - the dose is adjusted individually depending on the initial level of gastric secretion, usually starting from 60 mg / day. If necessary, increase the dose to 80-120 mg / day, in this case, it is divided into 2 doses.
Overdose
Symptoms: blurred vision, drowsiness, agitation, confusion, headache, increased sweating, dry mouth, nausea, arrhythmia.
Treatment: symptomatic. There is no specific antidote. Hemodialysis is not effective enough.
Special instructions
Before starting therapy, it is necessary to exclude the presence of a malignant process (especially in case of a stomach ulcer), since treatment, masking the symptoms, may delay the correct diagnosis.
Reception along with food does not affect the effectiveness.
If you have difficulty in swallowing a whole capsule, you can swallow its contents after opening or resorbing the capsule, and you can also mix the contents of the capsule with a slightly acidified liquid (juice,yoghurt) and use the resulting suspension for 30 minutes.
In patients with severe liver failure, the daily dose should not exceed 20 mg.
Storage conditions
In the dark place at a temperature of no higher than 25 ° C.
Shelf life
2 years
Pharmacy sales terms
On prescription