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Mechanism of action

Histamine N blocker1-receptors. Blocks histamine H1receptors and m-cholinergic CNS. It inhibits the vestibular apparatus of the inner ear, acting primarily on the otoliths, in high doses - on the semicircular canals. The main effect of dimenhydrinate is realized due to the blockade of m-cholinergic receptors. It has an antiemetic, sedative effect, eliminates dizziness.

After ingestion, dimenhydrinate is well absorbed and distributed to organs and tissues. The effect of the drug is manifested after 15-30 minutes and lasts for 3-6 hours. About 78% of dimenhydrinate binds to plasma proteins. Dimenhydrinate is metabolized in the liver and is almost completely excreted in the urine within 24 hours. Small amounts are excreted in breast milk. T1/2 Dimenhydrinate is about 3.5 h.

Indications and usage

- sea and air sickness;

- prevention and treatment of symptoms of vestibular and labyrinth disorders (dizziness, nausea, vomiting), with the exception of symptoms caused by antitumor therapy;

- symptomatic treatment of Meniere's disease.

Is inside, before eating.

Sea and air sickness

For the prevention of motion sickness, the first dose should be taken 30-60 minutes before the start of the movement.

Children aged 6-12 years: on 1 / 2-1 tab. (25-50 mg) every 6-8 hours, but not more than 3 tab. (150 mg) for 24 hours.

Adults and children 12 years and older: 1-2 tab. (50-100 mg) every 4-6 hours, but not more than 8 tab. (400 mg) for 24 hours

Prevention and treatment of symptoms of vestibular and labyrinth disorders (dizziness, nausea, vomiting), with the exception of symptoms caused by antitumor therapy

Children aged 6-12 years: on 1 / 2-1 tab. (25-50 mg) every 6-8 hours, but not more than 3 tab. (150 mg) for 24 hours.

Adults and children over 12 years old: 1-2 tab. (50-100 mg) every 4-6 hours, but not more than 8 tab. (400 mg) for 24 hours

Symptomatic therapy of Meniere's disease

Children aged 6-12 years: on 1 / 2-1 tab. (25-50 mg) every 6-8 hours, but not more than 3 tab. (150 mg) for 24 hours.

Adults and children over 12 years old: 1-2 tab. (50-100 mg) every 4-6 hours, but not more than 8 tab. (400 mg) for 24 hours

Elderly patients The drug should be taken in the minimum recommended dose for adults.

The duration of the drug and the possibility of repeating the course of treatment - in consultation with the doctor.

Adverse reactions

Determination of the frequency of adverse reactions: very often (≥1 / 10 cases), often (≥1 / 100 and <1/10 cases), infrequently (≥1 / 1000 and <1/100 cases), rarely (≥1 / 10 000 and <1/1000 cases) and very rarely (<1/10 000 cases, including individual reports).

From the side of the central nervous system: very often - dizziness, drowsiness, impaired concentration; often - general weakness, fatigue, anxiety, nervousness; rarely - headache, insomnia.

From the senses: often - weakening of night and color vision, blurred vision, disturbance of accommodation.

From the digestive system: often - dry mouth, nausea, vomiting; very rarely - loss of appetite.

On the part of the respiratory system: infrequently - dryness of the mucous membrane of the nose and throat, thickening of bronchial secretions.

Since the cardiovascular system: rarely - lowering blood pressure, tachycardia.

Allergic reactions: rarely, skin rash, medical dermatitis; very rarely - angioedema, bronchospasm.

From the urinary system: rarely - difficulty urinating.

Other: rarely - hemolytic anemia.

If any of the above adverse reactions are exacerbated, or the patient has noticed any other adverse effects, he should inform the doctor.

- Hypersensitivity to dimenhydrinate or other components of the drug;

- children's age up to 6 years;

- breastfeeding period.

Carefully: convulsive syndrome, angle-closure glaucoma, prostatic hyperplasia, bronchial asthma, cardiovascular diseases, hyperthyroidism, stenosing peptic ulcer, pyloroduodenal obstruction and obstruction of the bladder neck.

Pregnancy and Breastfeeding

Use of the drug during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

The use of the drug during breastfeeding is contraindicated. If necessary, use of the drug, breast-feeding should be discontinued.

Contraindication: children's age up to 6 years.

Elderly patients The drug should be taken in the minimum recommended dose for adults.

Special notes

With the use of dimenhydrinate, false-negative results of allergy tests are possible. Allergic tests should be carried out no earlier than 3 days after the end of the administration of dimenhydrinate.

Dimenhydrinate may show a false increase in theophylline level in the blood when it is determined by the immunological method.

Dimenhydrinate may mask the symptoms of ototoxicity and contribute to the development of irreversible hearing loss, and therefore its simultaneous use with ototoxic antibiotics is not recommended.

Dimenhydrinate is metabolized in the liver, and therefore care should be taken when using the drug in patients with liver failure.

Influence on ability to drive motor transport and control mechanisms

Given the side effect of dimenhydrinate, care should be taken when driving and engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Overdosage

Symptoms: dry mouth, nose and throat, redness of the face, slow and difficult breathing, confusion, in children - cramps, hallucinations. When these symptoms appear, an urgent need to consult a doctor.

Treatment: gastric lavage with a suspension of Activated carbon (20-30 g), the appointment of saline laxative (10-15 g of sodium sulfate), symptomatic therapy, with convulsions in children - phenobarbital (5-6 mg / kg), diazepam.

Drug Interactions

Dimenhydrinate enhances the action of atropine, tricyclic antidepressants, catecholamines, barbiturates, ethanol, sedatives and hypnotics, neuroleptics.

Dimenhydrinate reduces the effect of corticosteroids, anticoagulants.

Dimenhydrinate reduces the response to apomorphine.

Dimenhydrinate reduces the depressive effect of acetylcholine on the heart muscle.

Simultaneous administration of dimenhydrinate with bismuth preparations, scopolamine, anesthetics and psychotropic drugs increases the likelihood of visual impairment.

The simultaneous use of the drug with ototoxic antibiotics (streptomycin, neomycin, biomycin, Amikacin, kanamycin) is not recommended, because Dimenhydrinate may mask the symptoms of ototoxicity and contribute to the development of irreversible hearing loss.

Storage conditions

The drug should be stored out of the reach of children, dry, protected from light, at a temperature not exceeding 25 ° C.

The drug is approved for use as a means of OTC.