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Film Coated Tablets orange, round, slightly biconvex, notched on one side; on a break - weight from white to slightly yellow color.
1 pill contains 400 mg of norfloxacin;
Excipients: povidone, sodium starch glycolate, microcrystalline cellulose, anhydrous colloidal silicon dioxide, Magnesium stearate, hydroxypropyl methylcellulose, talc, titanium dioxide, dispersion yellow dye (Е104), propylene glycol.
10 pieces. in blister strip packagings, 1 or 2 packs in a carton box.
Nolicin - an antimicrobial drug of the fluoroquinolone group of a broad spectrum of action. Bactericidal effect. Inhibits bacterial DNA girazu, thereby preventing the replication of bacterial DNA and disrupts the synthesis of proteins, leading to the death of microorganisms.
Nolicin active against most gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp., Enterobacter spp., Serratia marcescens, Citrobacter spp., Yersinia enterocolitica, Providencia spp., Haemophilus influenzae, and they have to be, and they will have to be, and they will have to be, and they will have to be, and they will be able to do so. It is also active against some gram-positive bacteria, including Staphylococcus spp. and microorganisms producing b-lactamase.
Nolicin less active in relation to Acinetobacter spp. and Enterococcus spp.
To drug are resistant anaerobic bacteria and streptococci.
Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- urinary tract infections;
- genital infections;
- gonococcal infection;
- gastrointestinal infections;
- travelers' diarrhea.
Prevention of sepsis in patients with neutropenia.
- pregnancy;
- lactation (breastfeeding);
- children's and teenage age up to 18 years;
- hypersensitivity to norfloxacin and other drugs of the fluoroquinolone group.
With acute uncomplicated cystitis appoint 400 mg 2 times / day for 3-5 days.
In acute urinary tract infections - 400 mg 2 times / day for 7-10 days.
With recurrent or chronic recurrent urinary tract infections - 400 mg 2 times / day for 4 weeks and 400 mg / day for up to 12 weeks in case of relapse.
With genital infections - 400-600 mg 2 times / day for 7 days.
With acute uncomplicated gonococcal infection prescribe the drug at a dose of 800 mg once.
With gastrointestinal infections - 400 mg 2 times / day for 3-5 days.
For the prevention of sepsis in patients with neutropenia - 400 mg 3 times / day for 8 weeks.
For the prevention of bacterial diarrhea in epidemically unfavorable areas - 400 mg 1 time / day.
Patients with renal failure at values QC from 10 to 30 ml / min the drug is prescribed at a dose of 400 mg 1 time / day.
The drug should be taken on an empty stomach (at least 1 h before a meal or 2 h after a meal) and should be washed down with a sufficient amount of liquid.
Gastrointestinal: nausea, anorexia, diarrhea; possibly transient increase in liver transaminases, alkaline phosphatase, LDH.
From the side of the central nervous system: headache, dizziness, fatigue, drowsiness, anxiety, irritability, fear, confusion, hallucinations, depression, tinnitus.
Musculoskeletal system: in some cases - tendonitis, tendon rupture.
From the laboratory indicators: may decrease hematocrit, eosinophilia, leukopenia, increasing the concentration of creatinine in plasma.
Allergic reactions: rarely - urticaria, rash, itching, anaphylactic shock.
With caution, the drug is prescribed to patients with epilepsy, seizures with a history of seizures, and severe renal impairment.
During the period of drug treatment, patients should receive a sufficient amount of fluid (under the control of diuresis).
An increase in prothrombin index was observed during therapy with Nolicin. During surgical interventions, the state of the blood coagulation system should be monitored.
During treatment with Nolicin, direct sunlight should be avoided.
When pains in the tendons or at the first signs of tendovaginitis appear, it is recommended to stop the drug.
Persistent diarrhea may be due to the development of pseudomembranous colitis, although it is rarely associated with therapy with norfloxacin.
Patients should avoid increased physical exertion during the period of treatment and immediately after completion of the course of treatment.
With simultaneous use of Nolicin with theophylline and cyclosporine, it is recommended to monitor plasma concentrations of the latter.
Antacids, sucralfate, iron or zinc should be taken 2 hours after taking Nolicin.
Milk and yoghurt reduce the absorption of norfloxacin, so the drug should be taken 1 hour before or 2 hours after a meal containing milk or yogurt.
Use in pediatrics
The drug should not be prescribed to children and adolescents, since the experience of using Nolicin in this category of patients is absent and the possibility of damage to the articular cartilage during the growth period cannot be completely ruled out.
Influence on ability to drive motor transport and control mechanisms
In connection with the possible occurrence of dizziness in patients taking Nolicin, caution should be exercised when driving a car and doing other potentially dangerous activities that require increased attention and speed of psychomotor reactions (especially while drinking alcohol).
Symptoms: nausea, vomiting, diarrhea; in more severe cases - dizziness, fatigue, confusion, convulsions.
Treatment: gastric lavage, careful observation of the patient; conducting symptomatic therapy.It is necessary to ensure sufficient intake of fluid into the body while maintaining proper diuresis.
With simultaneous use of Nolicin with theophylline and cyclosporine, it is possible to increase the concentration of the latter in the blood plasma.
With the simultaneous use of Nolicin with Warfarin may increase the therapeutic effect of the latter.
With the simultaneous use of Nolicin and antacid agents, sucralfate, iron or zinc preparations, the absorption intensity of norfloxacin is reduced.
With the simultaneous use of quinolones and corticosteroids increases the risk of tendonitis and tendon rupture.
With simultaneous use of norfloxacin with hypoglycemic drugs derived from sulfonylurea, the hypoglycemic effect of the latter has been increased.
With simultaneous use of norfloxacin and nitrofurantoin, the effects of both drugs are reduced.
The preparation should be stored in a place protected from light and moisture at a temperature not exceeding 25 ° C.
- 5 years.
Nolitsin