EsCordi Cor pill 2.5mg №30

Composition and release form

EsCordi Cor - tablets:

1 tab. contains Amlodipine (in the form of besylate) 2.5 and 5 mg, excipients: microcrystalline cellulose, lactose, colloidal silicon dioxide, Magnesium stearate, croscarmellose sodium, ferric oxide yellow; in the package 30 pcs.

pharmachologic effect

Escordi Cor is a slow Calcium channel blocker derived from dihydropyridine. It has antianginal and hypotensive effects. By binding to the dihydropyridine receptors S (-), amlodipine is more potent than the R (+) isomer, blocks calcium channels, reduces the transmembrane transition of calcium ions into the cell (more in vascular smooth muscle cells than in cardiomyocytes).

Escordi Cor has a long dose-dependent hypotensive effect. The hypotensive effect is due to the direct vasodilating effect on vascular smooth muscle. In hypertension, a single dose provides a clinically significant reduction in blood pressure for 24 hours (in the position of the patient lying and standing). The onset of the effect is 2-4 hours, the duration of the effect is 24 hours.

Indications

Arterial hypertension I (mild) severity (in combination with other antihypertensive drugs or as monotherapy).

Contraindications

Hypersensitivity to S (-) amlodipine and other dihydropyridine derivatives;

Prinzmetal angina pectoris;

severe hypotension;

collapse, cardiogenic shock;

pregnancy and lactation;

age up to 18 years (efficacy and safety have not been established).

Side effects

Cardiovascular: palpitations, shortness of breath, marked reduction in blood pressure, fainting, vasculitis, edema (swelling of the ankles and feet), "flushes" of blood to the face, rarely - rhythm disturbance (bradycardia, ventricular tachycardia, atrial fibrillation), pain in chest, orthostatic hypotension, very rarely - development or aggravation of heart failure, migraine.

From the side of the central nervous system: dizziness, headache, fatigue, drowsiness, change of mood; rarely - convulsions, loss of consciousness, hyperesthesia, nervousness, parasthesia, tremor, vertigo, asthenia, malaise, insomnia, depression, extraordinary dreams, very rarely - ataxia, apathy, agitation, amnesia.

On the part of the digestive system: nausea, vomiting, epigastric pain; rarely, increased levels of liver enzymes and jaundice (caused by cholestasis), pancreatitis, dry mouth, flatulence, gingival hyperplasia, constipation or diarrhea, very rarely, gastritis, increased appetite, a violation of taste.

From the genitourinary system: rarely - pollakiuria, painful urge to urinate, nocturia, reduced potency; very rarely - dysuria, polyuria.

For the skin: very rarely - xerodermia, alopecia, dermatitis, purpura, discoloration of the skin.

Allergic reactions: pruritus, rash (including erythematous, maculopapular rash, urticaria), angioedema.

On the part of the musculoskeletal system: rarely - arthralgia, arthrosis, myalgia (with prolonged use); very rarely - myasthenia.

Other: rarely - gynecomastia, polyurikemia, weight gain / loss, thrombocytopenia, leukopenia, hyperglycemia, blurred vision, conjunctivitis, diplopia, eye pain, tinnitus, back pain, dyspnea, nasal bleeding, increased sweating, thirst; very rarely - cold sticky sweat, cough, rhinitis, parosmia, accommodation disturbance, xerophthalmia.

Dosage and administration

The recommended starting dose of Escordi Cora is 2.5 mg once daily.

The maximum dose can be increased with insufficient therapeutic effect of up to 5 mg once a day.

Storage conditions and shelf life

The drug should be stored out of reach of children at a temperature not exceeding 20 ° C. Shelf life - 2 years.