Flagyl pills 250mg №20

Packaging

20 pcs.

Mechanism of action

Flagyl is an antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of Metronidazole with intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole interacts with the microbial cell DNA, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria. It is active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp., As well as obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides theses, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella bucsechе, hе,,ительныхительных Eе грааоложааааааааааааааааааааааааааааааааааааааааааааааааа, Prevotella (Prevotella bivia, Prevotella bucеааааасе., Vevonella spp., Prevotella (Prevotella bivia, Prevotella bucеаааасе., Prevotella (Prevotella bivia, Prevotella bucsea, oo) Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 mcg / ml. In combination with Amoxicillin, it is active against Helicobacter pylori (amoxicillin inhibits the development of metronidazole resistance). Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics that are effective against ordinary aerobes.It increases the sensitivity of tumors to radiation, causes disulfiram-like reactions, stimulates reparative processes.

Indications and usage

Protozoal infections: extraintestinal amebiasis, including amebic liver abscess, intestinal amebiasis (amoebic dysentery), trichomoniasis, giardiasis, balantidiasis, giardiasis, cutaneous leishmaniasis, trichomonas vaginitis, trichomoniasis urethritis. Infections caused by Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): infections of bones and joints, infections of the central nervous system, including meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis. Infections caused by Clostridium spp., Peptococcus and Peptostreptococcus: abdominal infections (peritonitis, liver abscess), pelvic infections (endometritis, abscess of the fallopian tubes and ovaries, vaginal arch infections). Pseudomembranous colitis (associated with the use of antibiotics). Gastritis or duodenal ulcer associated with Helicobacter pylori. Prevention of postoperative complications (especially interventions on the colon, near-rectal area, apendectomy, gynecological surgery). Radiation therapy of patients with tumors - as a radiosensitizing drug in cases when tumor resistance is due to hypoxia in the tumor cells.

Hypersensitivity, leukopenia (including history), organic lesions of the central nervous system (including epilepsy), liver failure (in the case of the appointment of large doses), pregnancy (I term), lactation. With caution: pregnancy (II -III trimesters), renal / hepatic failure.

Dosage and administration

Inside, during or after a meal (or squeezed milk), not liquid. With trichomoniasis - 250 mg 2 times a day for 10 days or 400 mg 2 times a day for 5-8 days.

Adverse reactions

From the digestive system: diarrhea, loss of appetite, nausea, vomiting, intestinal colic, constipation, "metallic" taste in the mouth, dry mouth, glossitis, stomatitis, pancreatitis.

The nervous system: dizziness, impaired coordination, ataxia, confusion, irritability, depression, irritability, weakness, insomnia, headache, convulsions, hallucinations, peripheral neuropathy.

Allergic reactions: urticaria, skin rash, skin flushing, nasal congestion, fever, arthralgia.

On the part of the urinary system: dysuria, cystitis, polyuria, urinary incontinence, candidiasis, urine staining in red-brown color.

Local reactions: thrombophlebitis (pain, hyperemia or swelling at the injection site).

Other: neutropenia, leukopenia, flattening of the T wave on the ECG.

At a temperature not higher than 25 ° С.

5 years.