Zorex capsules 250mg + 10mg №2

Composition

Zorex capsules
1 capsule contains: active substances: Unithiol (2,3-dimercaptopropanesulfonate sodium) - 150 mg and Calcium pantothenate - 7 mg or unithiol (2,3-dimercaptopropanesulfonate sodium) - 250 mg and calcium pantothenate - 10 mg;
Excipients: microcrystalline cellulose, citric acid, starch 1500, Magnesium hydrogen phosphate (disubstituted magnesium phosphate), povidone, colloidal silicon dioxide.
Hard gelatin capsules: gelatin, titanium dioxide, azorubine, ponso 4R.

Capsules No. 0 for dosage 150 mg + 7 mg and capsules No. 00 for dosage 250 mg + 10 mg, body white, pink cap. The contents of the capsules are granules and white powder with a creamy shade.

LS - 000886

Pharmacological properties
Zorex has a detoxification (including with respect to the half-life of ethyl alcohol, heavy metals and their compounds, arsenic compounds) action. The clinical studies have shown the hepatoprotective and antioxidant properties of unithiol.

Active The sulfhydryl groups of the unithiol, interacting with the thiol poisons and the half-life of alcohol (ethanol) in the blood and tissues, form with them non-toxic compounds (complexes) that are excreted in the urine.

When taking the drug inside the active substance unithiol with portal blood flow penetrates the liver, where it is irreversibly and physiologically irreversibly bound to acetaldehyde, which causes the subsequent elimination of ethyl alcohol from other organs and tissues. Zorex also activates alcohol dehydrogenase, enhancing the oxidation of ethanol and detoxifying its toxic agents with the enzyme system of the liver.
Calcium Pantothenate enhances the detoxification effect of unitiol.

Indications and usage

• Alcohol abuse;
• Alcohol withdrawal syndrome;
• Chronic alcoholism (as part of complex therapy);
• Acute and chronic poisoning with organic and inorganic compounds of arsenic, mercury, gold, chromium, cadmium, cobalt, copper, zinc, nickel, bismuth, antimony, intoxication with cardiac glycosides.

Contraindications

Hypersensitivity to the components of the drug, severe decompensated diseases of the liver and kidneys.
Be wary when using low blood pressure.

Dosage and administration

capsules are taken orally 30 minutes before meals, without chewing, squeezed water.

At abuse alcoholic drinks or alcohol withdrawal syndrome - 1 capsule (250mg + 10mg) 1-2 times a day. If necessary, the daily dose can be increased to 1000 mg, and the frequency of administration should be increased to 3 times per day. The drug should be taken 3-7 days, until the cessation of symptoms of intoxication.
At chronic alcoholism: 1 capsule (150 mg + 7 mg) 1-2 times a day, for 10 days.
In case of poisoning with arsenic compounds and heavy metal salts - 300-1000 mg per day for 2-3 doses, for 7-10 days.

Adverse reactions

Seldom: allergic reactions, when used in high doses: nausea, dizziness, tachycardia, pallor of the skin.

Overdosage

Manifestations of overdose may occur when the recommended dose is exceeded by more than 10 times.
Symptoms: dyspnea, hyperkinesis, lethargy, lethargy, stupor, short-term seizures.
Treatment: gastric lavage, the appointment of Activated carbon, laxatives, symptomatic therapy, in acute cases, oxygen therapy, the introduction of dextrose, etc.

Drug interactions

not compatible with drugs containing salts of heavy metals, as well as with alkalis (rapidly decomposes).

Dosage form

2 or 10 capsules in a blister pack together with the application instruction in a cardboard pack

Storage conditions

List B. The drug should be stored in a dry, dark place, out of reach of children, at a temperature not higher than 25 ° C.
Shelf life - 2 years.