Moxonidine pills 200mcg №14

Packaging

14 pcs.

Mechanism of action

Moxonidine is a selective imidazoline receptor agonist that is responsible for the tonic and reflex control of the sympathetic nervous system (localized in the ventro-lateral part of the medulla). Slightly binds to central alpha2-adrenergic receptors, lowers blood pressure. With long-term use, it reduces LV myocardial hypertrophy, eliminates the signs of myocardial fibrosis, microarteriopathy, normalizes the capillary blood supply of the myocardium, reduces CRPS, pulmonary vascular resistance. The treatment reduces the concentration of norepinephrine and epinephrine, renin, angiotensin II at rest and during exercise, atrial natriuretic factor (during exercise), and plasma aldosterone. It reduces tissue resistance to insulin, stimulates the release of growth hormone. Does not affect the exchange of glucose and lipids. The interval between the achievement of Cmax and a pronounced decrease in blood pressure at rest differs on average by 10%, with a load of 7.7%. The duration of action is more than 12 hours (it is slowly excreted from the central nervous system and for a long time reduces the concentration of epinephrine in the plasma).

Overdosage

Symptoms: excessively pronounced decrease in blood pressure, dry mouth, palpitations, weakness, drowsiness.
Treatment: symptomatic. As a specific antidote, idazoxane (an imidazoline antagonist) is administered.

In a dry, dark place.