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Cosmetic brands
Nystatin pills coated 500000ed №100
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Packaging
10 pills in a blister pack. (package number 10 × 10).
Mechanism of action
Antifungal drugs, antibiotics
Polyene antifungal antibiotic, highly active against yeast-like fungi of the genus Candida. The structure of the antibiotic has double bonds that have a high tropism for the sterol structures of the cytoplasmic membrane of fungi, which contributes to the incorporation of the drug molecule into the cell membrane and the formation of a large number of channels through which uncontrolled transport of electrolytes takes place; an increase in osmolarity inside the cell leads to its death. Resistance develops very slowly.
Indications and usage
Treatment and prevention (with long-term drug treatment of penicillin and Tetracycline, chloramphenicol, etc.) candidiasis of the gastrointestinal tract.
Prevention of fungal lesions in the pre- and postoperative periods during surgical interventions in the gastrointestinal tract.
Pregnancy and Breastfeeding
Although Nystatin is absorbed in small quantities, it is not known whether it is excreted in breast milk, therefore, if it is necessary to use it during lactation, it is necessary to decide whether to stop breastfeeding.
Impact on ability to drive vehicles and machinery
When taken in therapeutic doses, nystatin does not affect the ability to drive vehicles and machinery.
Active ingredient
Each pill contains:
The active substance - nystatin - 500,000 U; excipients: potato starch, lactose monohydrate, stearic acid, talc, gelatin, opadry II (including: polyvinyl alcohol, partially hydrolyzed, talc, macrogol 3350, lecithin (soy), coloring pigment of yellow color (contains titanium dioxide E 171, indigo carmine E 132, and yellow quinoline E 104)), vanillin.
Dosage and Administration
The drug should be taken orally, regardless of the meal. The pills are swallowed without chewing.
Adults appoint 500 000 IU 3 - 4 times a day. Daily dose - 1500000 - 3000000 IU, in severe cases - up to 4,000,000 - 6000000 IU.
Children over 13 years old - 500 000 IU 3–4 times a day.
The duration of treatment is 10-14 days.
In chronic recurrent and generalized candidiasis, repeated courses are conducted at intervals of 2 to 3 weeks.
This dosage form is not intended for children under 13 years of age. Suspension should be intended for patients of this age group.
Adverse reactions
Nausea, vomiting, diarrhea, abdominal pain, chills, allergic reactions.
Overdosage
Phenomena of overdose with the use of the drug has not yet been described.