Retinol acetate oil solution 3.44% 10ml

Solution for oral and external use

Composition

1 ml of solution contains retinol acetate 3.44% -100000 IU

Fl. 10 ml.

Mechanism of action

Retinol acetate solution in oil has the effect of compensating for vitamin A deficiency. Regulation of vitamin A-dependent metabolic processes.

Indications and usage

Hypovitaminosis A, infectious diseases (measles, dysentery, tracheitis, bronchitis, pneumonia); skin diseases (burns, frostbite, wounds, skin tuberculosis, hyperkeratosis, ichthyosis, psoriasis, pyoderma, some forms of eczema); eye diseases (retinitis pigmentosa, hemeralopia, xerophthalmia, keratomalacia, conjunctivitis); chronic enterocolitis, hepatitis.

Contraindications

Gallstone disease, chronic pancreatitis.

Dosage and administration

The use of the drug should be carried out under medical supervision. The drug is taken orally (10 - 15 minutes after eating) in the early morning or late evening.

The highest single therapeutic dose for adults is 50,000 IU, daily 100,000 IU; for children, respectively - 5,000 IU and 20,000 IU.

For therapeutic purposes, mild to moderate avitaminosis is prescribed to adults up to 33,000 IU per day (retinol acetate solution in oil 3.44% - 6 drops), children over 7 years old - 5,000 IU per day (1 drop of retinol acetate solution in oil 3.44%).

In case of eye diseases, adults are prescribed - 50,000-100,000 IU per day (retinol acetate solution in oil, 3.44% -10-20 drops) and 0.02 g of riboflavin at the same time.

For skin diseases, adults are prescribed per day for 50,000-100,000 IU of retinol acetate and 5,000-10000-20000 IU for children.

Outwardly prescribed for frostbite, burns. After cleaning, the affected area is smeared with a solution and covered with a gauze bandage (up to 5 - 6 times a day, as scarring and epithelialization is reduced, the frequency of lubrication is 1 time per day), while retinol is administered orally or intramuscularly.

Adverse reactions

Allergic reactions.

Long-term daily intake of vitamin A can cause intoxication, hypervitaminosis A. Symptoms of hypervitaminosis A in adults - headache, drowsiness, lethargy, facial hyperemia, nausea, vomiting, pain in the bones of the lower extremities, gait disturbance. Children may experience: fever, drowsiness, sweating, vomiting, skin rashes.

Do not take at the same time other multivitamin complexes containing vitamin A, in order to avoid overdose.

Drug Interactions

During long-term Tetracycline therapy, it is not recommended to prescribe vitamin A (the risk of developing intracranial hypertension increases).

Salicylates and glucocorticosteroids reduce the risk of side effects.

Kolestiramin, Kolestipol, mineral oils, neomycin reduce the absorption of vitamin A (may require an increase in dose)

Oral contraceptives increase the concentration of vitamin A in plasma.

Isotretinoin increases the risk of a toxic effect.

Overdosage

Symptoms of acute overdose(develop 6 hours after administration):

hypervitaminosis A: in adults - drowsiness, lethargy, double vision, dizziness, severe headache, nausea, indomitable vomiting, diarrhea, irritability, bleeding gums, dryness and ulceration of the oral mucosa, peeling of the lips, skin (especially palms), confusion consciousness, increased intracranial pressure (in infants - hydrocephalus, protrusion fontanel).

Symptoms of chronic intoxication: loss of appetite, bone pain, cracks and dryness of the skin, dryness of the oral mucosa, lips, gastralgia, vomiting, hyperthermia, asthenia, excessive fatigue, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow-orange spots on soles, palms, in the area of ​​the nasolabial triangle, hepatotoxic effects, intraocular hypertension, oligomenorrhea, portal hypertension, hemolytic anemia, changes on radiographs of the bones, convulsions.

Treatment: drug withdrawal; symptomatic therapy.

Storage conditions

In the dark place at a temperature not exceeding +10 ° C. Keep out of the reach of children.