Crestor 20 mg pills №28

Dosage form

Pills

Composition

Active substance: Rosuvastatin 10, 20, or 40 mg in the form of rosuvastatin Calcium.

Excipients: lactose monohydrate, microcrystalline cellulose, calcium phosphate, crospovidone, Magnesium stearate, hypromellose, glycerol triacetate, titanium dioxide (E171), iron red oxide (E172), purified water.

Packing

28 pieces

Mechanism of action

CRESTOR reduces high cholesterol.

Indications and usage

Primary hypercholesterolemia (type IIa, including familial heterozygous hypercholesterolemia) or mixed hypercholesterolemia (type IIb) as a supplement to the diet, when diet and other non-drug therapies (eg exercise, weight loss) are insufficient.

Familial homozygous hypercholesterolemia as an adjunct to diet and other cholesterol-lowering therapy (for example, LDL-apheresis), or in cases where such therapy is not suitable for the patient.

Contraindications

- Liver diseases in the active phase, including a persistent increase in serum transaminase activity and any increase in serum transaminase activity (more than 3 times as compared with VGN);

- Severe renal dysfunction (CC <30 ml / min);

- Myopathy;

- Simultaneous reception of cyclosporine;

- Pregnancy;

- Lactation period (breastfeeding);

- Lack of adequate methods of contraception;

- Predisposition to the development of myotoxic complications;

- lactose intolerance, lactase deficiency or glucose-galactose malabsorption (the product contains lactose);

- Hypersensitivity to the drug.

Dosage and administration

Inside, do not chew or crush the pill, swallow whole, washed down with water. May be appointed at any time of the day, regardless of the meal. If necessary, take the drug in a dose of 5 mg should be divided pill Crestor 10 mg. Before starting treatment with Crestor, the patient should begin to follow a standard lipid-lowering diet and continue to follow it during treatment. The dose of the drug should be chosen individually depending on the goals of therapy and the response to treatment, taking into account the current recommendations on target lipid levels. The recommended initial dose for patients starting to take the drug, or for patients transferred from receiving other HMG-CoA reductase inhibitor, should be 5 or 10 mg of Crestor 1 time per day. When choosing the initial dose, one should be guided by the individual cholesterol levels and take into account the risk of cardiovascular complications, and the potential risk of side effects should be assessed. If necessary, the dose may be increased to a maximum after 4 weeks (seesection "Pharmacodynamics"). Due to the possible development of side effects when taking a dose of 40 mg, compared with lower doses of the drug (see the section “Side Effects”), increasing the dose to 40 mg after an additional dose of the drug is higher than the recommended initial dose within 4 weeks treatment can only be carried out in patients with severe hypercholesterolemia and with a high risk of cardiovascular complications (especially in patients with familial hypercholesterolemia) who have not achieved the desired result of therapy when taking a dose of 20 mg and who will find sya under the supervision of a specialist (in lipidologicheskih, Diabetes or cardiac clinics) (see. "Special Instructions" section). Especially careful monitoring of patients receiving the drug at a dose of 40 mg is recommended. It is not recommended to administer a dose of 40 mg to patients who have not previously contacted specialists. After 2-4 weeks of therapy and / or with an increase in the dose of Crestor, control of lipid metabolism indices is necessary (dose adjustment is required if necessary).

Overdosage

With simultaneous administration of several daily doses, the pharmacokinetic parameters of rosuvastatin do not change.

Treatment: there is no specific antidote. It is recommended to carry out symptomatic treatment and measures aimed at maintaining the functions of vital organs and systems. The control of liver function and the level of CPK is necessary. It is unlikely that hemodialysis will be effective.

Storage conditions

At a temperature not higher than 30 ° C.

3 years