Broncho-munal p capsules 3.5 mg №10

Mechanism of action

Combined immunomodulatory drug of bacterial origin. Stimulates both the local cellular and humoral immune response in the mucous membrane of the respiratory tract and the systemic immune response. The drug stimulates the activity of alveolar macrophages, increases the number and activity of T-lymphocytes, activates peripheral monocytes, increases the concentration of secretory IgA on the mucous membranes of the respiratory tract and digestive tract, stimulates the production of protective adhesive molecules, reduces the concentration of IgE antibodies in the blood, also increases the production of cytokines.

After taking the drug inside the antigen is captured by the APC cells of the mucous membrane of the gastrointestinal tract. Antigen-stimulated APC cells enter lymphoid organs (for example, Peyer's patches), where they “present” the antigen to lymphoblasts. Then, antigen-stimulated and IgA-committed lymphoblasts migrate with lymph flow through the thoracic duct into the blood and with the blood flow into the mucous membranes (including the respiratory tract), where they are converted into plasma cells and synthesize IgA. Further, IgA is transported to the surface of the mucous membranes in the form of a double molecule, preventing the effects of infectious agents.

Indications and usage

For prophylaxis and as part of combination therapy of infectious and inflammatory diseases of the respiratory tract:
- Chronical bronchitis;
- tonsillitis, pharyngitis, laryngitis;
- rhinitis, sinusitis, otitis media.

For prevention of infectious diseases of the respiratory tract appoint 1 caps. / day for 10 days a month for 3 months. Each month, the drug should be taken whenever possible on the same days as the previous one.
Adults and children over 12 years old prescribe Broncho-Munal in a dose of 7 mg; children aged 6 months to 12 years prescribe Broncho-Munal P at a dose of 3.5 mg.
For treatment of infectious diseases of the respiratory tract appoint 1 caps / day for at least 10 days. If necessary, a combination with antibiotics. In the next 2 months, prophylactic use of the drug in 1 capsule is possible for 10 days with a 20-day interval between courses.
The drug is taken in the morning on an empty stomach.
If the child cannot swallow the capsule, it is recommended to open it, and dissolve the contents of the capsule in a small amount of liquid (tea, milk or juice).

Adverse reactions

Gastrointestinal: rarely - epigastric pain, nausea, vomiting, diarrhea.
Other: rarely - fever, skin allergies.

Contraindications

- Hypersensitivity to the drug.

Pregnancy and breastfeeding

Adequate and strictly controlled clinical studies of the safety of the use of the drug Broncho-Munal during pregnancy and lactation (breastfeeding) were not conducted.
If necessary, the use of the drug during lactation should decide on the termination of breastfeeding (due to the lack of data on the secretion of the active substance in breast milk).

Special notes

Between the use of oral vaccines and taking Broncho-Munala should observe a 4-week interval.
Do not recommend the use of Broncho-Munal in acute intestinal diseases due to a possible reduction in the effectiveness of the drug.
Use in pediatrics
The drug is not prescribed children under 6 months. In order to avoid overdose, children are prescribed only capsules containing 3.5 mg of lyophilisate.

Overdosage

Currently, cases of overdose of the drug Broncho-Munal were reported.

Drug Interactions

Drug interaction of the drug Broncho-Munal is not described.

Storage conditions

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C. Shelf life - 5 years.