Fluoxetine capsules 10mg №20

Overdosage

Symptoms: convulsions, nausea, vomiting, state of agitation.
Treatment: it is necessary to wash the stomach, give activated charcoal, in case of convulsions to appoint tranquilizers.

Cautions

When treating patients with a body mass deficiency, anorexigenic effects should be taken into account (progressive loss of body weight is possible).
In diabetics, the prescription of Fluoxetine increases the risk of hypoglycemia and hyperglycemia when it is canceled. In this regard, the dose of insulin and / or any other hypoglycemic drugs used orally must be adjusted. Before the onset of a significant improvement in treatment, patients should be under the supervision of a physician.
During treatment, one should refrain from taking ethanol and practicing potentially hazardous activities that require increased attention and speed of mental and motor responses.
The interval between the end of therapy with MAO inhibitors and the start of treatment with fluoxetine should be at least 14 days; between the end of treatment with fluoxetine and the start of therapy with MAO inhibitors - at least 5 weeks.
With liver disease and in old age, treatment should begin with a half dose.

Drug Interactions

Enhances the effects of alprazolam, diazepam, ethanol and hypoglycemic drugs.
Increases in plasma the concentration of phenytoin, tricyclic antidepressants, maprotiline, trazodone 2 times (it is necessary to reduce the dose of tricyclic antidepressants by 50% with simultaneous use). On the background of electroconvulsive therapy, the development of long-term epileptic seizures is possible.
Tryptophan increases the serotonergic properties of fluoxetine (increased agitation, motor anxiety, disorders of the gastrointestinal tract).
MAO inhibitors increase the risk of serotonin syndrome (hyperthermia, chills, increased sweating, myoclonus, hyperreflexia, tremor, diarrhea, impaired motor coordination, autonomic lability, agitation, delirium and coma).
Drugs that have a depressant effect on the central nervous system increase the risk of side effects and enhance the inhibitory effect on the central nervous system.
With simultaneous use with drugs with a high degree of protein binding, especially with anticoagulants and digitoxin, it is possible to increase the concentration in plasma of free (unbound) drugs and increase the risk of adverse effects.

The drug should be stored in a dry, dark place.

- 2 years.