Buy Seroquel coated tablets 100mg №60
  • Buy Seroquel coated tablets 100mg №60

Seroquel pills 100mg №60

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Pills

Composition

Quetiapine Fumarate

Excipients: Povidone, Calcium hydrophosphate, microcrystalline cellulose, sodium carboxymethyl starch, lactose monohydrate, Magnesium stearate.

Packing

60 pieces

Mechanism of action

SEROQUEL - antipsychotic medication (neuroleptic). Shows higher affinity for serotonin 5HT2-receptors (compared to dopamine D1- and D2-receptors) in the brain. It also has a high affinity for histamine and α1-adrenoreceptors and less active in relation to α2-adrenoreceptors. Does not possess affinity to m-cholinergic receptors and benzodiazepine receptors.

Showed antipsychotic activity in standard tests.

The results of the study of extrapyramidal symptoms in animals revealed that Quetiapine causes only weak catalepsy when exposed to a dose that effectively blocks dopamine D2receptors. Quetiapine selectively reduces the activity of mesolimbic A10dopaminergic neurons compared to A9-nigrostrial neurons involved in motor function.

Clinical studies (using Seroquel in doses of 75-750 mg) did not reveal differences between Seroquel and placebo in the frequency of occurrence of extrapyramidal symptoms and concomitantuse of anticholinergic drugs.

Seroquel does not cause prolonged increase in the level of prolactin in the blood plasma. In numerous studies with a fixed dose did not reveal differences in the level of prolactin when using Seroquel or placebo.

In clinical studies Seroquel It has been shown to be effective in treating the positive and negative symptoms of schizophrenia.

Effects of Quetiapine on 5HT2- and D2-receptors last up to 12 hours after taking the drug.

Indications and usage

- treatment of acute and chronic psychosis, including schizophrenia;

- treatment of manic episodes in the structure of bipolar disorder;

- treatment of depressive episodes of moderate to severe severity in the structure of bipolar disorder (within 8 weeks).

Contraindications

- combined use with cytochrome P450 inhibitors (antifungals of the azoles group, Erythromycin, Clarithromycin, nefazodone, protease inhibitors);

- Hypersensitivity to any of the components of the drug.

Dosage and administration

Seroquel should be taken 2 times / day, regardless of the meal.

for treatment of acute and chronic psychosis, including schizophrenia, The daily dose for the first 4 days of therapy is: 1st day - 50 mg, 2nd day - 100 mg, 3rd day - 200 mg, 4th day - 300 mg.

Depending on the clinical effect and individual tolerance of the patient, the dose can vary from 150 mg to 750 mg / day.The maximum daily dose is 750 mg.

For treatment of manic episodes in the structure of bipolar disorder Seroquel used as monotherapy or as adjuvant therapy to stabilize mood.

The daily dose for the first 4 days of therapy is: 1st day - 100 mg, 2nd day - 200 mg, 3rd day - 300 mg, 4th day - 400 mg. In the future, by the 6th day of therapy, the daily dose of the drug can be increased to 800 mg. The increase in the daily dose should not exceed 200 mg / day.

Depending on the clinical effect and individual tolerance, the dose can vary from 200 mg to 800 mg / day. Usually, the effective dose ranges from 400 mg to 800 mg / day. The maximum daily dose is 800 mg.

For treatment of depressive episodes in the structure of bipolar disorder Seroquel appoint 1 time / day. for the night. The recommended dose is 300 mg. The daily dose for the first 4 days of therapy is: 1st day - 50 mg, 2nd day - 100 mg, 3rd day - 200 mg, 4th day - 300 mg. The maximum daily dose is 600 mg. No clinical improvement was noted with increasing doses of more than 600 mg.

Have elderly patients The initial dose is 25 mg / day. The dose should be increased daily by 25-50 mg to achieve an effective dose, which is likely to be less than in younger patients.

Have patients with renal or hepatic insufficiency It is recommended to start Seroquel therapy with 25 mg / day. It is recommended to increase the dose daily by 25-50 mg to achieve an effective dose.

Safety and efficacy of Seroquel children and teenagers not explored.

Adverse reactions

Nervous system: often - drowsiness (17.5%), dizziness (10%); rarely - neuroleptic malignant syndrome (hyperthermia, impaired consciousness, muscle rigidity, vegetative-vascular disorders, increased concentration of CPK); very rarely - seizures. With long-term use of Seroquel there is a potential for the development of tardive dyskinesia. If symptoms of tardive dyskinesia occur, reduce the dose or discontinue further treatment with Seroquel.

Gastrointestinal: often - constipation (9%), dyspepsia (6%), dry mouth (7%); increased activity of liver enzymes (ALT, AST, GGT) in the serum (6%), as well as an increase in the concentration of cholesterol and triglycerides (during the treatment with Seroquel, these changes were usually reversible).

Cardiovascular: often - orthostatic hypotension (accompanied by dizziness), tachycardia (7%), fainting; these adverse reactions are mainly found in the initial period of dose selection.

Hemic and lymphatic: rarely, leukopenia and / or neutropenia. No cases of severe neutropenia or agranulocytosis have been observed in patients taking Seroquel. When using Seroquel in clinical practice, leukopenia and / or neutropenia were resolved after discontinuation of the drug. Possible risk factors for the development of leukopenia and / or neutropenia include a decrease in the number of leukocytes before the start of therapy or a history of leukopenia and / or neutropenia, caused by medication.

On the part of the endocrine system: Seroquel therapy is associated with a small dose-dependent decrease in thyroid hormone levels, in particular, total T4 and free T4. Maximum reduction in total and free T4 registered on the 2nd and 4th week of quetiapine therapy without further reducing the concentration of hormones during long-term treatment. In the future, there were no signs of clinically significant changes in the concentration of thyroid stimulating hormone. In almost all cases, the concentration of total and free T4 returned to baseline after discontinuing Seroquel, regardless of the duration of treatment.

Allergic reactions: rarely - eosinophilia, allergic reactions, including angioedema.

Other: rarely - peripheral edema, moderate asthenia, rhinitis, weight gain (mainly in the first weeks of treatment); very rarely - priapism.

Overdosage

Symptoms: The symptoms noted were mainly due to the enhancement of the known pharmacological effects of the drug, such as drowsiness and excessive sedation, tachycardia and a decrease in blood pressure.

Treatment: There are no specific antidotes for Quetiapine. In cases of severe intoxication, it is necessary to consider the possibility of symptomatic therapy and it is recommended to carry out activities aimed at maintaining the function of respiration, the cardiovascular system, ensuring adequate oxygenation and ventilation. Medical control and monitoring should be continued until the patient is fully cured.

Storage conditions

At temperatures below 30 ° C.

3 years

Seroquel