Macropen powder for suspension preparation 175mg/5ml 115ml bottle

Mechanism of action

Macropene is an antibiotic of the macrolide group. Inhibits protein synthesis in bacterial cells. Reversibly binds to the 50S subunit of the bacterial ribosomal membrane. In low doses, the drug has a bacteriostatic effect, in high doses it is bactericidal.
Active against intracellular microorganisms: Mycoplasma spp., Chlamydia spp., Legionella spp., Ureaplasma urealyticum;against gram-positive bacteria: Streptococcus spp., Staphylococcus spp., Corynebacterium diphtheriae, Listeria monocytogenes, Erysipelothrix spp., Clostridium spp.;Gram-negative bacteria: Neisseria spp., Moraxella catarrhalis, Bordetella pertussis, Helicobacter spp., Campylobacter spp., Bacteroides spp.

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- infections of the respiratory tract, urinary system, genital organs caused by Mycoplasma spp., Chlamydia spp., Legionella spp. and Ureaplasma urealyticum;
- infections of the respiratory tract, skin and subcutaneous tissue caused by microorganisms sensitive to penicillin;
- treatment of infections in patients with hypersensitivity to penicillin antibiotics;
- treatment of enteritis caused by Campylobacter spp.;
- treatment and prevention of diphtheria and whooping cough.

Contraindications

- severe degree of liver failure;
- Hypersensitivity to midecamycin / myocamycin and other components of the drug.

Pregnancy and Breastfeeding

The use of Macropen during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus.
Midecamycin is excreted in breast milk. When using Macropen during lactation, breastfeeding should be stopped.

Dosage and administration

The drug should be taken before meals.

The scheme of appointment of Macropene in the form of a suspension for children (daily dose of 50 mg / kg body weight) is presented in the table.

The duration of treatment is from 7 to 14 days, with treatment of chlamydial infections - 14 days.
To prepare the suspension, add 100 ml of boiled or distilled water to the contents of the vial and shake well.

Adverse reactions

Gastrointestinal: possible loss of appetite, stomatitis, nausea, vomiting, diarrhea, increased activity of hepatic transaminases and jaundice; rarely - a feeling of heaviness in the epigastrium; in some cases, severe and prolonged diarrhea, which may indicate the development of pseudomembranous colitis.
Allergic reactions: skin rash, urticaria, itching, eosinophilia are possible.

As with the use of any other antimicrobial drugs, with long-term treatment with Macropen, excessive growth of resistant bacteria is possible.Prolonged diarrhea may indicate the development of pseudomembranous colitis.
With prolonged therapy, liver enzyme activity should be monitored, especially in patients with impaired liver function.
Influence on ability to drive motor transport and control mechanisms
Not reported on the effect of Macropen on the speed of psychomotor reactions and ability to drive a car and other mechanisms.

Drug Interactions

With simultaneous use of Macropen with ergot alkaloids, Carbamazepine, their metabolism in the liver decreases and serum concentration increases. The simultaneous appointment of these drugs with Macropen is not recommended.
With simultaneous use of Macropen with cyclosporine, Warfarin slows down the excretion of the latter.

Overdosage

There are no reported cases of serious intoxication caused by the drug Macropen.
Symptoms: nausea, vomiting are possible.
Treatment: conducting symptomatic therapy.

The preparation should be stored in protected from moisture, the place inaccessible for children at a temperature not above 25 ° C.