Enalapril pills 5 mg №28

Pharmacological action: Hypotensive, vasodilator. Blocks the ACE, reduces post-and preload, inhibits the synthesis of aldosterone in the adrenal glands. Pharmacokinetics: Rapidly and adequately absorbed by oral administration. In the body it is hydrolyzed, forming an active enalaprilat. Indications: essential hypertension of all degrees of severity, renovascular hypertension, heart failure stage I-III; to reduce the incidence of myocardial infarction in patients with left ventricular dysfunction, the risk of mortality and the frequency of hospitalization for unstable angina. Contraindications: Hypersensitivity (to any of the components of the drug), angioedema in history. Use during pregnancy and lactation: In pregnant women, they are used only for health reasons (death of the fetus or newborn is possible). At appointment to nursing mothers it is necessary to be careful (it is desirable to refuse breastfeeding). Side effects: Dizziness, headache, fatigue, asthenia, hypotension (including orthostatic), fainting, nausea, diarrhea, muscle cramps, rash, cough, hypersensitivity reaction (angioedema of the face, lips, tongue, glottis, larynx, limbs). Interaction: Compatible with other antihypertensive drugs (additive effect). Reduces hypokalemia induced by diuretics.Combined use with potassium-sparing diuretics or potassium-enriched salt contributes to the increase of serum potassium. Reduces Cl lithium. Overdose: Symptoms: hypotension (6 hours after taking the drug), stupor. Treatment: in / in the introduction of isotonic solution, gastric lavage, hemodialysis. Dosage and administration: Inside, once - 10-20 mg, maximum dose - 40 mg; with renovascular hypertension - 2.5-5 mg, with congestive heart failure, they start with 2.5 mg, then the dose is gradually increased to 20 mg. Against the background of renal failure, the daily dose is reduced (depending on Cl creatinine). Precautions: Before and during treatment, monitoring of blood pressure, kidney function, and potassium in plasma is necessary. In patients with reduced BCC (as a result of diuretic therapy), while limiting salt intake, dialysis, diarrhea and vomiting, symptomatic hypotension may develop. Be sure to carefully monitor patients with severe heart failure, coronary heart disease and vascular diseases of the brain, because a sharp decrease in blood pressure can lead to myocardial infarction or stroke, impaired renal function. The drug is dialysis; correction dosage in the days when dialysis is not carried out, should be carried out depending on the level of blood pressure; The use of AN69 dialysis membranes in combination with ACE inhibitors is not recommended.