Theotard capsule retard 350mg №40

Packaging

In the blister 10 capsules. In packing 4 blisters.

Mechanism of action

Theothard is a pure anhydrous theophylline (a derivative of xanthine) in the form of granules. Theophylline is a phosphodiesterase inhibitor that increases the accumulation of c-AMP in tissues, which reduces the contractile activity of smooth muscles. It has a pronounced bronchodilator effect, prevents or eliminates bronchial obstruction. Improving lung function can increase the supply of arterial blood with oxygen, which leads to a decrease in CO 2 concentration. It has a stimulating effect on the respiratory center, reduces pulmonary vascular resistance, lowers blood pressure in the pulmonary circulation. Improves mucociliary clearance. It has a positive inotropic and chronotropic effect on the heart. Stimulates diuresis. Expands blood vessels (mainly vessels of the brain, skin and kidneys). Inhibits platelet aggregation. After oral administration, Teotard is almost completely absorbed.

The slow release of the active substance from the retard capsules of the preparation Teotard ensures the maintenance of a uniform level of theophylline in the blood serum for 12 hours. Teothard's bronchodilator effect develops gradually, so the drug is not prescribed for the relief of emergency conditions.

Indications and usage

Treatment and prevention of reversible bronchial obstruction in:
- Bronchial asthma.
- Chronic obstructive bronchitis.
- Emphysema of the lungs.

Contraindications

- Hypersensitivity to theophylline.
- Pregnancy.
- Lactation.
- Epilepsy.
- Acute myocardial infarction.
- Extrasystole.
- Peptic ulcer of the stomach and duodenum in the acute stage.
- Children's age up to 3 years.

Caution and dose reduction are needed:

- With severe violations of the liver and kidneys.
- In acute heart failure.

Pregnancy and Breastfeeding

Contraindicated in pregnancy and lactation.

Dosage and administration

Capsules of the drug should not be opened or chewed. The dosage of the drug is individual. It is unacceptable to exceed the daily dose of 15 mg / kg in adults, 20 mg / kg in children. For the selection of the dose of the drug is necessary to determine the concentration of theophylline in the serum. As a rule, the concentration of theophylline in the serum from 10 to 15 mg / ml provides a therapeutic effect with minimal risk of side effects.If the concentration exceeds 20 mg / ml, the dose should be reduced.

During the first three days, take one retard capsule of the drug every 12 hours. On the third day, you should evaluate the effectiveness of therapy and tolerability of the drug. With insufficient efficacy, the dose may be increased. In case of undesirable side effects, the dose should be reduced.

TeoTard 350 mg is prescribed for adults and children whose body weight exceeds 40 kg. Morning and evening doses of the drug may be different depending on the time of occurrence of attacks of difficulty breathing, the clinical picture of the disease and the effectiveness of therapy.

Overdosage

Symptoms: overdose of the drug in individual patients can cause pain in the stomach, nausea, vomiting, diarrhea, headache, heart rhythm disturbances, tachycardia, low blood pressure, increased angina attacks, insomnia, tremor, irritability, increased diuresis, hyperglycemia, hypokalemia. Possible skin rash, itching.
Treatment: in these cases, the dose must be reduced.

Store at a temperature not exceeding 25 ° C, protected from light and moisture.