Pirazidol pills 25mg №50

Mechanism of action

Antidepressant. Combines the thymoleptic effect with a balanced effect on the central nervous system, while the activating effect in patients with apathetic, anergic depressions is combined with a sedative effect in patients with an agitated condition.
Selectively, briefly and reversibly inhibits MAO type A; to a high degree blocks deamination of serotonin and norepinephrine, and to a lesser extent, tyramine. Partially inhibits monoamine reuptake. It activates the processes of synaptic transmission of nervous excitement in the central nervous system.
Weakens the depressive effects of reserpine, potentiates the effects of the precursor of norepinephrine - dioxyphenylalanine (L-dopa), stimulates adrenergic structures; potentiates the effects of serotonin precursor 5-hydroxytryptophan (stimulates serotonergic structures).
Does not possess anticholinergic action. It has a nootropic effect, improves cognitive function.

Data on the pharmacokinetics of the drug Pyrazidol not provided.

Indications and usage

- depression of various genesis, mainly with psychomotor retardation and asthenic disorders, anxiety-depressive or anxiety-delusional components;
- senile, involutional depression;
- alcohol withdrawal syndrome;
- Alzheimer's disease (as part of complex therapy).

Adverse reactions

Gastrointestinal: dry mouth, nausea.
Nervous system: tremor, vertigo.
Other: sweating, tachycardia, allergic reactions.

Contraindications

- acute hepatitis;
- blood diseases;
- simultaneous administration of MAO inhibitors and a period of up to 14 days after their cancellation;
- hypersensitivity to the drug.

Pregnancy and breastfeeding

Adequate and strictly controlled studies on the safety and efficacy of the drug during pregnancy and lactation have not been conducted.

Pyrazidol is not prescribed simultaneously with MAO antidepressants, inhibitors, furazolidone, procarbazine, selegiline.
Perhaps the use of pyrazidol in patients with glaucoma and benign prostatic hyperplasia.
Pyrazidol is compatible with antipsychotics, anxiolytics.

Overdosage

Data on drug overdose Pyrazidol not provided.

Drug Interactions

With simultaneous use increases the effectiveness of epinephrine (due to anti-monoamine oxidase activity).

Storage conditions

List B. The drug should be stored in a dry, dark place at temperatures not above 25 ° C.