Haloperidol pills 1.5mg №50

Mechanism of action

Neuroleptic. The mechanism of pronounced antipsychotic action is associated with the blockade of dopamine receptors in the central nervous system. Causes moderate sedation. In addition, the drug has antiemetic, analgesic, antipyretic, anticonvulsant and antihistamine action.

Suction
When ingested, about 70% of the dose is absorbed from the gastrointestinal tract.
Distribution
When administered parenterally, 92% of the active substance binds to plasma proteins.
Metabolism
Haloperidol is metabolized in the liver.
Removal
Excreted in the urine and bile, undergoes hepatic recycling.
T_1/2 is 13-40 hours

Indications and usage

- psychomotor agitation of various genesis (including with mania, dementia, oligophrenia, psychopathy, acute and chronic schizophrenia, chronic alcoholism);
- delusions and hallucinations of various origins (in acute and chronic schizophrenia, paranoid states, acute psychosis);
- acute anxiety-depressive syndrome with arousal (agitated depression);
- Chorea of ​​Huntington;
- excitement, aggressiveness, behavior disorders in the elderly and children;
- stuttering;
- Vomiting and hiccups lasting for a long time, resistant to therapy;
- Gilles de la Tourette syndrome.

Set individually depending on the age, clinical presentation and previous reactions of the patient to other antipsychotics.
At acute psychosis adults are administered the drug in a dose of 5-10 mg IM / IV. If necessary, the drug in the specified dose can be re-administered 1-2 times with a 30-40 minute interval to obtain the desired therapeutic effect. The maximum daily dose is 30-40 mg.
When acute alcoholic psychosis Haloperidol administered in / in a dose of 5-10 mg, if necessary, repeat the introduction of the drug.
At alcoholic deliriumaccompanied by anxiety, Haloperidol is administered in / in the form of an infusion at a dose of 10-20 mg; usually the rate of administration is 5-10 mg / min (not more than 5 mg / 30 sec).
For ingestion, the average daily intake for adults makes 2.25-18 mg. If necessary, the specified dose can be increased to obtain a sustainable therapeutic effect, and then gradually reduced to a lower maintenance dose.
In the absence of clinical improvement within 1 month, it is not recommended to continue treatment.

Adverse reactions

From the side of the central nervous system: drowsiness may occur at the beginning of therapy; with longer use possible akinesia, tremor, increased muscle tone and other symptoms of parkinsonism, as well as the development of tardive dyskinesia.

Contraindications

- diseases of the central nervous system, accompanied by pyramidal or extrapyramidal disorders;
- pregnancy;
- lactation (breastfeeding);
- depressive states (except agitated depressions).

Pregnancy and breastfeeding

Haloperidol is contraindicated for use during pregnancy due to the possibility of its negative impact on the development of the fetus.
If necessary, the use of haloperidol during lactation should stop breastfeeding.

Cautions

During the period of use of the drug is prohibited alcohol.
In the case of simultaneous use of haloperidol and indirect anticoagulants with the abolition of haloperidol, the dose of the anticoagulant should be adjusted.
Drowsiness and symptoms of parkinsonism that occur when taking Haloperidol, spontaneously stop with a decrease in the dose of the drug or a temporary cessation of treatment. In the case of the development of tardive dyskinesia, it is necessary to gradually reduce the dose of haloperidol and prescribe another drug.
Influence on ability to drive motor transport and control mechanisms
Patients taking Haloperidol should refrain from engaging in potentially hazardous activities that require increased attention and quick psychomotor reactions.

Overdosage

Symptoms: muscle rigidity, general or local tremor, drowsiness, arterial hypotension, sometimes - arterial hypertension. In extremely severe cases - coma, respiratory depression, shock.
Treatment: there is no specific antidote.In the case of taking the drug inside, if the patient's condition allows, you can wash out the stomach, and then appoint activated charcoal. When respiratory depression is necessary to resort to mechanical ventilation. To improve blood circulation in / injected plasma or albumin solution, as well as norepinephrine (adrenaline in these cases is strictly prohibited to use!). In order to reduce the severity of extrapyramidal symptoms, a parenteral anti-Parkinsonian drug, such as benztropine mesylate, should be administered parenterally.

Drug Interactions

With simultaneous use, Haloperidol potentiates the action of antihypertensive agents, opioid analgesics, barbiturates, antidepressants, ethanol and ethanol-containing drugs.
With the simultaneous use of haloperidol and indirect anticoagulants, a decrease in the effect of the latter is observed.

Storage conditions

List B. The drug should be stored at room temperature. Shelf life - 2 years.