Syresp syrup 2mg/ml bottle 150ml

Dosage Form

Syrup

Pharmacotherapeutic group

Other drugs for systemic use in obstructive respiratory diseases.

Pharmacological properties

Fenspyrid counteracts bronchoconstriction and has anti-inflammatory effect.

This action is the result of the interaction of various interrelated mechanisms:

- antagonistic activity at the level of histamine Hi-receptors and papaverine-like (myotropic) antispasmodic action;

- The anti-inflammatory effect is the result of a decrease in the production of various pro-inflammatory factors (cytokines, TNFα, arachidonic acid derivatives and free radicals), some of which also have a bronchoconstrictor effect. However, these effects were observed only at very high doses or concentrations.

After oral administration, the maximum concentration of serum fenspiride is achieved on average from 0.5 hours to 8 hours. The half-life is about 12 hours. Fenspirid is excreted mainly through the kidneys.

Indications

Symptomatic treatment of respiratory diseases (coughing and expectoration). Taking this drug should not delay the start of antibiotic therapy, if necessary.

Contraindications

Hypersensitivity to the active substance and / or to any excipient of the drug.Children under 2 years. Syresp contains sucrose, so patients with rare genetic disorders associated with fructose intolerance, poor glucose absorption syndrome - galactose or sucrase deficiency - isomaltase should not take the drug Syresp.

Interaction with other drugs

The interaction of fenspiride with other drugs is unknown. However, taking into account the antihistamine effect of fenspiride, one can expect interaction with:

- barbiturates

- other antihistamine, analgesic, narcotic, sedative drugs, MAO inhibitors, alcohol.

Special notes

With the infectious nature of the disease, treatment with Syresp is carried out along with standard antibiotic therapy.

The drug can cause allergic reactions (possible reactions with delayed action) due to the content of preservatives - methyl and propyl parahydroxybenzoate.

5 ml of syrup contains 3 g of sucrose, which must be taken into account when prescribing it to patients with diabetes.

The drug contains the dye sun-sunset yellow, which can cause allergic reactions (reactions with a delayed action are possible).

Pregnanacy and breastfeeding

Taking the drug Syresp during pregnancy is not recommended.

There is no data indicating the penetration of fenspiride into the mother's milk, but it is not recommended to take the drug during breastfeeding.

Influence on ability to driving of vehicles and control of mechanisms

Research on the effect of Syresp syrup on the ability to drive vehicles and control mechanisms, was not conducted.

Dosage and administration

Take orally before eating. Children over 2 years old:

The usual recommended dose is 4 mg of fenspiride hydrochloride / kg per day.

Up to 10 kg:

2-4 scoops (or 10-20 ml) of Syresp syrup (20-40 mg of fenspiride hydrochloride) per day.

More than 10 kg:

6-12 scoops (or 30-60 ml) of Syresp syrup (60-120 mg of fenspiride hydrochloride) per day, the dose should be divided into several doses.

Adults and teenagers:

9-18 scoops (or 45-90 ml) of Syresp syrup per day (90-180 mg of fenspiride hydrochloride) per day, the dose should be divided into several doses.

A scoop with a scale of 1.25 ml, 2.5 ml and 5 ml of syrup is attached to the package. The duration of treatment is determined by the attending physician.

5 ml of syrup contains 10 mg of fenspiride hydrochloride and 3 g of sucrose (which is 0.25 bread units).

Overdosage

In case of overdose, drowsiness or agitation, nausea, vomiting, tachycardia may occur.

Treatment: gastric lavage, ECG monitoring.

Adverse effects

Side effects are classified by frequency of occurrence using the following definitions:

- very often:> 1/10

- often:> 1/100 to <1/10

- infrequently:> 1/1000 to <1/100

- rarely:> 1/10 000 to <1/1000

- very rarely: <1/10 000

Unknown (Cannot determine frequency based on available data).

Heart disorders

Rare: moderate tachycardia, which ceases with decreasing dosage.

From the digestive system

Often: nausea, stomach pain, gastrointestinal disorders.

Unknown: diarrhea, vomiting.

Allergic reactions

Rarely: erythema, angioedema, fixed erythema pigment, rash; due to the presence of parahydroxybenzoate in the composition of the syrup, it is possible to develop urticaria.

Nervous system disorders

Rare: drowsiness.

Unknown: dizziness.

The occurrence of all adverse (unusual) effects, including those not listed in the package leaflet, must be reported to your doctor.

After the first opening of the package, the bottle must be used within 6 months.

Do not use after the expiration date printed on the package.

Storage conditions

In the original packaging to protect from light at a temperature not higher than 25 ° C. Keep out of the reach of children.