Metadoxil ampoules 300mg 5ml №10

Ampoules, 5 ml.

Composition

:

Metadoxin (pyridoxine L-2 pyrrolidone 5-carboxylate), 300 mg

Sodium metabisulphite; sodium edetate; methyl p-hydroxybenzoate; water for injections

Packaging

10 ampoules

Mechanism of action

Metadoxil has a detoxification and cytoprotective effect. Stimulates oxidation and accelerates the elimination of ethanol, restores the ratio of saturated and unsaturated free fatty acids in plasma, preventing the primary structural degeneration of hepatocytes, inhibits the formation of fibronectin and collagen.

Indications and usage

Complex therapy of liver diseases, especially alcoholic etiology; acute alcohol intoxication; chronic alcoholism; alcohol withdrawal syndrome.

Contraindications

Hypersensitivity to any component of the drug; pregnancy; lactation period.

Pregnancy and Breastfeeding

Contraindicated.

Dosage and administration

For acute alcohol intoxication, depending on the degree of intoxication, 300-600 mg (5-10 ml) or 300-900 mg (5-15 ml) are injected into the drug.

With the on / in the introduction of the required dose of the drug is diluted in 500 ml of isotonic sodium chloride solution or 5% dextrose solution (glucose) and injected drip for 1.5 h.

Toxic damage to the liver of alcoholic etiology, prevention of the formation of cirrhosis of alcoholic origin and chronic alcoholism: inside 500 mg (1 tablet) 2 (1 g /) 15-30 minutes before a meal. The dose can be increased to 500 mg 3 (1.5 g /) or injected intramuscularly at a dose of 300 mg (5 ml) / The course of treatment is at least 90 days.

When alcohol withdrawal syndrome in / in the form of an infusion in a dose of 900 mg (15 ml) 1 time / for 3-7 days depending on the patient's condition.

Adverse reactions

Possible: allergic reactions. Patients with asthma may develop bronchospasm.

Drug Interactions

When used together, it reduces the effectiveness of levodopa.

Storage conditions

Store in a dark place at a temperature not higher than 25 ° C.