Ovestin vaginal cream with applicator 1 mg \ 1g 15g

Dosage form

Cream

Packing

15 g

Mechanism of action

OVESTIN - estriol is a natural estrogen. It contributes to the restoration of normal vaginal epithelium with its atrophic changes in pre- and postmenopause, contributes to the normalization of the microflora of the vagina, thereby increasing the resistance of the epithelium of the vagina to infectious and inflammatory processes. Since estriol has a short duration of action, taking the drug once daily in a dose does not cause endometrial proliferation and does not require additional progestogen therapy. Consequently, there is no withdrawal bleeding.
It has no significant effect on mineral and protein metabolism, blood glucose level, peripheral blood picture, plasma phosphorus content.

Indications and usage

- Atrophy of the mucous membrane of the lower urogenital tract, associated estrogen deficiency;
- pre- and postoperative treatment of women in the postmenopausal period with vaginal access operations;
- infertility caused by cervical factors;
- for diagnostic purposes with unclear results of a vaginal smear on cytology.

Contraindications

- pregnancy;
- thrombosis, embolism;
- severe liver dysfunction;
- hormone-dependent tumors of the uterus or mammary glands;
- uterine bleeding of unknown etiology.

Dosage and administration

The drug is equally effective when taken orally and with intravaginal (in the form of suppositories and cream) use.
Inside the drug is prescribed in the initial daily dose of 4-8 mg in 1 reception for 2-3 weeks; then gradually reduce the dose to 1-2 mg / day.
Vaginal suppositories are used at a dose of 500 mcg / day every day for the first 2-3 weeks; then gradually reduce the dose to 500 mcg / day, 2 times a week.
The cream is administered intravaginally at 500 mcg / day daily in the first weeks of treatment with a gradual transition to a maintenance dose (500 mcg / day 2 times a week).

The daily dose should not exceed 8 mg by ingestion, with intravaginal use - cream 1 time / day and 1 candle per day. The duration of treatment with the indicated maximum doses should not exceed several weeks.
It is recommended to carefully monitor patients who have or had the following conditions: thrombosis, severe liver dysfunction, porphyria, this category includes persons who have experienced severe itching, cholestatic jaundice, herpes of pregnancy or otosclerosis.
The patient should consult a physician if relief of symptoms does not occur after 2-3 weeks of drug treatment.

Storage conditions

The drug should be stored at room temperature (not above 25 ° C).