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Klacid pills 500mg №14
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coated tablets
Composition
1 pill contains Clarithromycin 500 mg
Packing
14 pcs.
Mechanism of action
Klacid is an antibiotic of macrolide group. Clarithromycin inhibits protein synthesis in the microbial cell by interacting with the 50S ribosomal subunit of bacteria.
Highly active against a wide range of aerobic, anaerobic, gram-positive and gram-negative bacteria. Clarithromycin has demonstrated high in vitro activity against standard and isolated bacterial cultures. Highly effective against many aerobic and anaerobic gram-positive and gram-negative microorganisms. In vitro studies confirm the high efficacy of clarithromycin against Legionella pneumophila and Mycoplasma pneumoniae.
The drug is also active against aerobic gram-positive microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Listeria monocytogenes; aerobic gram-negative microorganisms: Haemophilus influenzae, Haemophilus parainftuenzae, Moraxella catarrhalis, Neisseria gonorrhoeae; other microorganisms: Mycoplasma pneumoniae, Chlamydia pneumoniae (TWAR), Chlamydia trachomatis, Mycobacterium Mycobacterium leprae, Mycobacterium kansasii, Mycobacterium chelonae, Mycobacterium fortuitum, Mycobacterium avium complex (Maccoterium chelonae chelonae, Mycobacterium fortuitum, Mycobacterium leprae, Mycobacterium chelonae, Mycobacterium leprae, Mycobacterium leprae, Mycobacterium pneumoniae, Mycobacterium, Mycobacterium, Mycobacterium, Mycobacterium, Mycobacterium, Mycobacterium, Mycobacterium, Mycobacterium, Mycobacterium, Mycobacterium
Enterobacteriaceae, Pseudomonas spp., As well as other gram-negative bacteria that do not decompose lactose, are insensitive to clarithromycin. The production of b-lactamase does not affect the activity of clarithromycin.Most of the methicillin and oxacillin resistant staphylococci strains are resistant to clarithromycin.
Indications and usage
Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- infections of the upper respiratory tract (pharyngitis, tonsillitis and sinusitis);
- infections of the lower respiratory tract (bronchitis, pneumonia);
- otitis media;
- infections of the skin and soft tissues (impetigo, folliculitis, cellulitis, abscesses);
- disseminated or localized mycobacterial infections caused by Mycobacterium avium or Mycobacterium intracellulare;
- localized infections caused by Mycobacterium fortuitum, Mycobacterium kansasii, Mycobacterium chelonae.
Contraindications
- pronounced renal dysfunction (with CC less than 30 ml / min); these patients are prescribed quick-release clarithromycin;
- simultaneous reception of astemizol, cisapride, pimozide, terfenadine;
- porphyria;
- pregnancy;
- lactation (breastfeeding);
- Hypersensitivity to macrolide antibiotics.
Dosage and administration
The average oral dose for adults is 250 mg 2 times / day. If necessary, you can assign 500 mg 2 times / day. Duration of treatment is 6-14 days.
For the treatment of infections caused by Mycobacterium avium, Klacid is prescribed by mouth - 1 g 2 times / day. The duration of treatment may be 6 months or more.
Adverse reactions
Cardiovascular: rarely, ventricular arrhythmia, including ventricular tachycardia (with an increase in the QT interval).
Gastrointestinal: nausea, abdominal pain, vomiting, diarrhea, gastralgia, pancreatitis, glossitis, stomatitis, oral candidiasis, discoloration of the tongue and teeth; rarely - pseudomembranous enterocolitis. Teeth discoloration is reversible and is usually restored by professional cleaning by a dentist. Liver dysfunction was rarely observed, incl. increased liver enzyme activity, hepatic cell and / or cholestatic hepatitis with or without jaundice. These abnormal liver functions can be severe, but usually they are reversible. Very rarely, there have been cases of liver failure and death mainly due to severe concomitant diseases and / or concomitant drug therapy.
From the side of the central nervous system: transient headaches, dizziness, anxiety, insomnia, nightmares, tinnitus, depersonalization, hallucinations, convulsions, fear; rarely - psychosis, confusion; in some cases, hearing loss (with the discontinuation of clarithromycin, hearing was restored), a change in smell (usually accompanied by distortion of taste sensations).
Allergic reactions: urticaria, skin flushing, pruritus, anaphylaxis, Stevens-Johnson syndrome.
Hemic and lymphatic: leukopenia, thrombocytopenia.
From the laboratory indicators: increased creatinine levels in the blood; rarely - hypoglycemia (while taking hypoglycemic drugs).
Other: development of microbial resistance.
Storage conditions
To store in protected from light, the place, inaccessible for children, at a temperature not above 30 ° C.
3 years.