Buy Ginalgin vaginal tablets №10
  • Buy Ginalgin vaginal tablets №10

Gynalgin vaginal pills №10

$23.94
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Composition

Metronidazole 250 mg, chlorquinaldol 100 mg.

Excipients: anhydrous citric acid, lactose monohydrate; rice starch; sodium starch glycolate (ultraamylopectin); polyethylene glycol 6000 (carbowax 6000); Magnesium stearate

Packing

10 pieces

Mechanism of action

Gynalgin - antibacterial, bactericidal, antifungal, antiprotozoal, trichomonacid action.

Combined preparation for intravaginal use.

Metronidazole refers to nitro-5-imidazoles. The mechanism of action of Metronidazole is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The restored 5-nitro group of metronidazole interacts with the microbial cell DNA, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Metronidazole is an effective antimicrobial and antiprotozoal agent of a wide spectrum of action. The drug exhibits high activity against Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis, as well as with respect to obligate anaerobes (spore and non spore forming) - Bacteroides spp. (B. fragilis, B. ovatus, B. distasonis, B. thetaiotaomicron, B. vulgatus), Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., Sensitive Eubacterium strains.

Aerobic microorganisms and facultative anaerobes are not sensitive to metronidazole.

Chlorquinaldol acts on the following strains of pathogenic bacteria: Corynebacterium diphtheriae, Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella, Shigella, Escherichia coli.

It also exhibits activity with respect to the simplest: Entamoeba histolytica, Lamblia intestinalis, Trichomonas vaginalis and some fungi.

Citric acid lowers the pH of the vagina, promotes the growth and reproduction of Doderlein sticks.

Indications and usage

Infectious and inflammatory diseases of the vagina caused by pathogens that are sensitive to the drug.

Contraindications

Hypersensitivity to metronidazole or other nitroimidazole derivatives; individual intolerance to chlorquinaldol and other ingredients that make up the vaginal tablets, blood disorders, leukopenia (including a history); lack of coordination of movements, organic lesions of the central nervous system (including epilepsy); liver failure (in the case of the appointment of large doses), pregnancy, breastfeeding.

Pregnancy and Breastfeeding

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Dosage and administration

Intravaginally. The pill is inserted deep into the vagina, preferably in the evening before bedtime, 1 tab. Once a day for 7–10 days. Treatment begins at 2–4 days after menstruation.

If necessary, may conduct a second course of treatment.

Adverse reactions

Itching, burning, pain and irritation in the vagina; thick, white, slimy discharge from the vagina, odorless or with a faint odor,frequent urination; after discontinuation of the drug - the development of vaginal candidiasis; burning sensation or irritation of the penis of the sexual partner; headache, dizziness, leukopenia, or leukocytosis; nausea, change in taste, metallic taste in the mouth, dry mouth, decreased appetite, cramped abdominal pain, vomiting, constipation or diarrhea; allergic reactions: urticaria, skin itching, rash.

In rare cases, it is possible to stain urine in a red-brown color due to the presence of a water-soluble pigment, resulting from the metabolism of metronidazole.

Special notes

Alcohol intake should be avoided (similar to disulfiram causes alcohol intolerance). During the period of drug treatment is recommended to refrain from sexual intercourse. With indications of a history of changes in the composition of peripheral blood, as well as with the use of the drug in high doses and / or with its long-term use, control of the complete blood count is necessary. Metronidazole can immobilize treponemas, which leads to a false-positive TPI test (Nelson's test).

It is necessary to pay attention of patients, especially drivers of vehicles and persons operating other mechanisms, to the possibility of dizziness associated with taking the drug.

Drug interactions

Metronidazole enhances the effect of indirect anticoagulants (for example, warfarin), which leads to an increase in the time of formation of prothrombin.

Simultaneous use with disulfiram can lead to the development of various neurological symptoms (depression of consciousness, development of mental disorders); therefore, Gynalgin should not be prescribed to patients who have taken disulfiram during the last 2 weeks.

Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in its concentration in serum and an increase in the risk of side effects.

When taken simultaneously with lithium preparations, the concentration of the latter in plasma may increase.

Possible reduction of the effect of Gynalgin under the influence of barbiturates, since inactivation of metronidazole in the liver is accelerated.

Storage conditions

In a dry place, at a temperature of 15-25 ° C.

Ginalgin