Sodium chloride ampoules 0.9% 10ml №10

Sodium Chloride 0.9%

Sodium chloride

Dosage form

powder for solution for injection, solution for infusion, solution for injection, solvent for preparation of dosage forms for injection, nasal spray

Mechanism of action

Plasma substitute. It has a detoxification and rehydrating effect. It compensates for the deficiency of Na + in various pathological conditions. 0.9% NaCl solution is isotonic to human plasma and therefore is rapidly excreted from the vascular bed, only temporarily increasing the BCC (efficacy in blood loss and shock is insufficient). Hypertonic solutions (3-5-10%) with external application contribute to the release of pus, exhibit antimicrobial activity, with intravenous administration increase diuresis and compensate for the deficiency of Na + and Cl-.

Indications and usage

0.9% NaCl solution - large losses of extracellular fluid or insufficient intake (toxic dyspepsia, cholera, diarrhea, "indomitable" vomiting, extensive burns with severe exudation, etc.), hypochloremia and hyponatremia with dehydration, intestinal obstruction, intoxication; washing the wounds, eyes, nasal mucosa, dissolving and dilution of drugs and moisturizing dressings.Hypertonic solution - pulmonary, gastric and intestinal bleeding, forced diuresis (auxiliary osmotic diuretic), dehydration, poisoning with silver nitrate, purulent wounds (local), constipation (rectal).

Contraindications

Hypernatraemia, acidosis, hyperchloremia, hypokalemia, extracellular overhydration; circulatory disorders threatening swelling of the brain and lungs; cerebral edema, pulmonary edema, acute LV failure, concomitant administration of GCS in high doses. C caution. Decompensated CHF, CRF (oligo-, anuria).

In / in, drip; n / a, rectally, topically, externally. 0.9% NaCl solution: before the introduction of the solution is heated to 36-38 degrees C. The dose is determined depending on the loss of body fluids, Na + and Cl- and an average of 1 l / day. With large losses of fluid and severe intoxication, it is possible to administer up to 3 l / day. The rate of injection is 540 ml / h; if necessary, the rate of administration is increased. Children with a pronounced decrease in blood pressure on the background of dehydration (until laboratory parameters are determined) are injected with 20-30 ml / kg. In the future, the dosing regimen is adjusted depending on laboratory parameters. With long-term administration of large doses of 0.9% NaCl solution, it is necessary to monitor electrolytes in the plasma and urine. 0.9% NaCl solution is used to wash wounds, eyes, nasal mucosa, moisturizing dressings. Hypertonic 10% solution is injected into / in the jet, in an amount of 20 ml; for washing the stomach - 2-5%, in enemas (100 ml) - 5% solution. Eye drops prescribed 1-2 drops in the affected eye during the daytime.In enemas - 100 ml of 5% solution to stimulate bowel movement with constipation or up to 3 l / day of 0.9% solution.

Adverse reactions

Acidosis, overhydration, hypokalemia.

Special notes

Possible freezing of the drug under the condition of the integrity of the tightness of the container. Control of EC and electrolytes.

Drug interactions

When mixed with other drugs, it is necessary to visually monitor compatibility (however, invisible and therapeutic incompatibility is possible).