Indinol forto capsules 200mg №60

Trade name: Indinol® Forto

Dosage Form: capsules
Composition:
1 capsule contains: active ingredient: indole carbinol and (intrinol) - 0.200 g;
excipients: lactose monohydrate (milk sugar) - 0.140 g, modified corn starch - 0.095 g, microcrystalline cellulose - 0.064 g, Magnesium stearate - 0.001 g.

Pharmacotherapeutic group: metabolic agent

Pharmacology

Indinol® Forto is a universal corrector of pathological hyperplastic processes in the tissues of the breast. The basis of the therapeutic effect of Indinol® Forto is its anti-estrogenic and anti-proliferative effect. The main property of Indinol® Forto is its ability to cause selective death of breast cells with abnormally high proliferative activity.
Indol carbinol, which is part of Indinol® Forto, modulates the cytochrome system in such a way that the resulting cytochrome P450 isoform - CYP1A1 hydroxylates the estrogens in the 2nd position, with the formation of 2-hydroxyestrone (2-OH1). The resulting metabolite is an estrogen receptor antagonist and blocks its activation by the estrogens themselves, as well as their dangerous metabolites, in particular, 16-alpha-hydroxyestron (16α-ONE), the proportion of which among metabolites decreases.Thus, the induction of estrogen-dependent genes is suppressed, and the cell stops receiving excessive estrogen-dependent stimulation. The drug also blocks other signaling mechanisms (cytokine) that stimulate abnormal cell growth in the breast tissue by suppressing signaling cascades from the corresponding receptors.
Course use of the drug helps to reduce the intensity and the disappearance of pain in the breast with cyclic mastalgia (mastodynia).
Use of the drug Indinol® Forto does not lead to an increase in body weight.
Indinol® Forto belongs to practically non-toxic drugs (LD50> 5 g / kg).

Indications and usage

Cyclic mastalgia, including against the background of benign breast hyperplasia.

Contraindications for use

The drug should not be used in the presence of any of the following conditions:
Hypersensitivity to the drug.
Hereditary intolerance to galactose, lactase deficiency or glucose-galactose malabsorption.
Period of pregnancy and breastfeeding.
Children's age up to 18 years.

Use during pregnancy and during breastfeeding

Use of the drug Indinol® Forto during pregnancy and breastfeeding is contraindicated.

Inside, 2 times a day, 200 mg. The daily dose of the drug is 400 mg. Capsules are taken before meals.Duration of treatment is 6 months.

Adverse reactions

Reproductive system: menstrual disorders in the form of lengthening or shortening.
On the part of the digestive system: pain in the epigastrium.
Laboratory indicators: an increase in the concentration of thyrotropic and follicle-stimulating hormones, prolactin and estradiol, a decrease in the concentration of creatinine, eosinophilia.
Other: weight loss.
If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects not mentioned in the instructions, notify your doctor.

Overdose

Possible symptoms of overdose include nausea, vomiting, diarrhea. The specific antidote is unknown. If overdose of Indinol® Forto is suspected, symptomatic therapy is recommended.

Interaction with other drugs

Indolkarbinol affect the activity of cytochrome P450 isoenzymes, so caution should be exercised when used together with drugs, metabolism involving isozymes of cytochrome P450 (oral anticoagulants, corticosteroids, oral hypoglycemic agents, antiarrhythmics, antiepileptics, digitalis preparations, preparations sex hormones) have been may require correction of their dose.

Influence on ability to drive vehicles and mechanisms

Based on the characteristics of pharmacodynamics and the profile of undesirable effects, it is unlikely that Indinol® Forto affects the ability to drive vehicles and work with equipment.

Release form
Capsules 200 mg.
On 20 capsules in a blister strip packaging from a film of polyvinyl chloride and aluminum foil lacquered printed.
60, 90 or 120 capsules in polymer cans, sealed with a stretchable plastic lid with the control of the first opening or in polymer cans for the packaging of medicines. 3 or 6 blister packs of 20 capsules, or each jar together with the instructions for use are placed in a pack of cardboard.

Shelf life:
Do not use beyond the expiration date printed on the package.

Storage conditions:
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.

Pharmacy sales conditions:
Prescription.