Atacand Plus 16mg pills + 12.5mg №28

Active ingredient and dosage form

Atakand plus pills:
1 pill contains 16 mg Candesartan cilexetil and hydrochlorothiazide 12.5 mg;
28 pcs. packaged.

Mechanism of action

Atacand has a hypotensive effect. Selectively blocks angiotensin II receptors (type AT1).

Atakand plus is a combined antihypertensive drug. Candesartan and hydrochlorothiazide have a potent hypotensive effect. In patients with arterial hypertension, Atacand Plus causes an effective and prolonged decrease in blood pressure without an increase in heart rate. Orthostatic hypotension at the first dose of the drug is not observed, after the end of treatment arterial hypertension does not increase.

Hydrochlorothiazide, a thiazide-like diuretic, inhibits the active reabsorption of sodium, mainly in the distal regions of the renal tubules and enhances the release of sodium, chlorine and water ions. The excretion of potassium and Magnesium by the kidneys increases with the dose, while Calcium begins to be reabsorbed in larger quantities than before.

Hydrochlorothiazide reduces the volume of blood plasma and extracellular fluid, reduces the intensity of blood transport by the heart, reduces blood pressure. During long-term treatment, the hypotensive effect develops due to the expansion of arterioles.With prolonged use of hydrochlorothiazide decreases the risk of cardiovascular diseases and mortality.

Indications and usage

Arterial hypertension.

Contraindications

Hypersensitivity; pregnancy, breastfeeding; childhood.

Adverse reactions

Headache, dizziness, back pain.

Dosage and administration

Inside, regardless of the meal, the recommended initial and maintenance dose of Atacand is 8 mg 1 time a day, if necessary, you can increase the dose to 16 mg 1 time a day.

If necessary, patients are transferred from Atacand monotherapy to Atacand Plus therapy. The main hypotensive effect is achieved, as a rule, in the first 4 weeks after the start of treatment.

Atacand Plus should be taken 1 time per day, regardless of the meal.

Special notes

Symptomatic hypotension, incl. in the treatment of high doses of diuretics, it is necessary to adjust before the start of therapy.

Store in a cool and dark place, protected from light and moisture, at a temperature not higher than 25 ° C.

Atakand plus