Keppra pills 1000mg №30

Indications and usage

Partial seizures with or without secondary generalization in adults and adolescents over 16 years of age with newly diagnosed epilepsy - as monotherapy (first choice drug).

Keppra is used as part of complex therapy in the treatment of the following conditions:

partial seizures with or without secondary generalization in adults and children over 4 years old with epilepsy;

myoclonic seizures in adults and in adolescents over 12 years of age suffering from juvenile myoclonic epilepsy;

primary generalized convulsive (tonic-clonic) seizures in adults and adolescents over 12 years of age, suffering from idiopathic generalized epilepsy.

Hypersensitivity to levetiracetam or other pyrrolidone derivatives, as well as to any components of Keppra;

violation of tolerance to fructose (solution);

children's age up to 4 years (safety and efficacy of the drug have not been established).

elderly patients (over 65 years);

severe abnormal liver function;

renal failure.

Pregnancy and Breastfeeding

Adequate and strictly controlled clinical studies on the safety of levetiracetam in pregnant women have not been carried out, so Keppra should not be prescribed during pregnancy, unless absolutely necessary. It should be borne in mind that interruptions in antiepileptic therapy may worsen the course of the disease, which can harm the health of both the mother and the fetus.

Levetiracetam is excreted in breast milk, so if you need to use it during lactation, breastfeeding at the time of taking the drug should be stopped.

Adverse reactions

Possible side effects when using Keppra are given below in descending frequency of occurrence: very often (and> 1/10), often (and> 1/100,and <1/10), including individual messages. There is no pronounced correlation of the incidence of side effects with the age of the patients.

On the part of the central nervous system and peripheral nervous system: very often - drowsiness or insomnia, depressive syndrome, emotional instability, aggressiveness, nervousness; often - dizziness, headache, amnesia, ataxia, convulsions, hyperkinesia, tremor, diplopia, disturbance of accommodation; individual messages - abnormal behavior, anger, anxiety, anxiety, confusion, hallucinations, irritability, psychotic disorders, suicide, suicide attempts, and suicidal thoughts.

On the part of the respiratory system: often - cough.

On the part of the digestive system: often - abdominal pain, diarrhea, dyspepsia, nausea, vomiting.

On the part of the skin: often - skin rash; individual messages - alopecia (in many cases, hair restoration was observed after discontinuation of the drug).

On the part of metabolism: often - anorexia.

Violations of a general nature: very often - asthenic syndrome; often - infectious diseases, accidental injuries.

From the laboratory indicators: individual messages - leukopenia, neutropenia, pancytopenia, thrombocytopenia.

Inside, drinking plenty of fluids, regardless of the meal. The daily dose of Keppra is divided into 2 identical doses.

In the case of a solution, dosing is carried out using a measuring syringe, which is included in the drug package, with a nominal capacity of 10 ml (which corresponds to 1000 mg of levetiracetam) with a division of 25 mg (which corresponds to 0.25 ml). Keppra measured dose is diluted in a glass of water.

As monotherapy

For adults and adolescents over the age of 16, the initial daily dose is 500 mg in 2 doses (250 mg 2 times a day). After 2 weeks, the dose can be increased to the initial therapeutic one - 1000 mg (500 mg 2 times a day). The maximum daily dose is 3000 mg (1500 mg 2 times a day).

As part of complex therapy

For children over 4 years old, the initial daily dose of Keppra is 20 mg / kg body weight in 2 doses (10 mg / kg body weight 2 times a day). A dose change of 20 mg / kg body weight can be carried out every 2 weeks until the recommended daily dose is reached - 60 mg / kg body weight (30 mg / kg body weight 2 times per day). In case of intolerance to the recommended daily dose, its reduction is possible.

Adults and adolescents over 16 years old with a body weight of more than 50 kg, the initial daily dose is 1000 mg in 2 doses (500 mg 2 times a day). Depending on the clinical response and tolerability of the drug, the daily dose may be increased to a maximum of 3000 mg (1500 mg 2 times a day). Changing the dose of 500 mg 2 times a day can be done every 2-4 weeks.

Storage conditions

In the dark place at a temperature of no higher than 20 ° C. Shelf life - 3 years.