Midzo drops for oral administration 60 mg/ml vial 15 ml №4

Composition

• Active ingredient: Cyanamide - 60 mg in 1 ml of the drug
• Excipients: sorbic acid - 0.2 mg, acetic acid - 0.47 mg, sodium acetate trihydrate - 0.47 mg, purified water - up to 1.0 ml.

Release form

Drops for oral administration in the form of a clear, colorless solution with a faint odor of acetic acid. On 15 ml in the bottle from the brown glass supplied with a nozzle dropper and the screwed cover. 4 bottles per pack.

Mechanism of action

Drugs used in alcohol dependence

The action of cyanamide is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol. This leads to an increase in the metabolite concentration of ethyl alcohol - acetaldehyde, which causes negative sensations (flushing, nausea, tachycardia, shortness of breath, etc.), which make alcohol use unpleasant after taking the drug. This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages.

The sensitizing effect of cyanamide on alcohol appears earlier (after about 45-60 minutes) and lasts shorter (about 12 hours) than the action of disulfiram.

Indications for use

Treatment of patients with chronic alcoholism and relapse prevention.

Dosage and administration

Treatment is prescribed after a thorough examination of the patient and warning about the consequences and complications.

The drug is administered orally by 12-25 drops (36-75 mg of cyanamide) 2 times a day with an interval of 12 hours according to an individual scheme.

Contraindications

• severe heart disease
• diseases of the respiratory tract and kidneys with a decrease in function,
• severe liver disease,
• pregnancy,
• breastfeeding period,
• increased individual sensitivity to the drug.

Special notes

MIDO should be used only under the supervision of a physician and with the knowledge of the patient. You may experience a reaction to alcohol contained in some drugs and food products.

Treatment Midzo can begin only after 12 hours since the last intake of alcohol. Cyanamide should be used with caution in cases where the reaction to the simultaneous intake with alcohol may entail a risk to the patient's health: in case of hyperthyroidism, diabetes mellitus, epilepsy, cardiovascular diseases, kidney diseases. With prolonged use, it is recommended to monitor the function of the thyroid gland at least once every six months.

At the same time taking the drug with alcohol, the following symptoms appear: severe redness of the skin, "pulsation" in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, excessive sweating, chest pain.In the most severe cases - vomiting, lowering blood pressure, respiratory depression, collaptoid state. The nature and severity of symptoms depend on the amount of alcohol taken and the drug. In severe cases, it is necessary to conduct symptomatic therapy aimed at maintaining the functions of the respiratory and cardiovascular systems, intravenous infusion of antihistamines.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.