Circadin pills prolong 2mg №21

Dosage form

Extended Release Tablets

Composition

1 tab. contains melatonin 2 mg

Packing

21 pieces

Mechanism of action

Analogue of the pineal gland hormone (epiphysis) melatonin; has an adaptogenic, sedative, hypnotic effect. Normalizes circadian rhythms. Increases the concentration of GABA and serotonin in the midbrain and hypothalamus, changes the activity of pyridoxal kinase involved in the synthesis of GABA, dopamine and serotonin. It regulates the sleep-wake cycle, diurnal changes in locomotor activity and body temperature, and has a positive effect on the intellectual-mental functions of the brain, on the emotional-personal sphere. Contributes to the organization of biological rhythm and the normalization of night sleep. Improves the quality of sleep, reduces the frequency of attacks of headaches, dizziness, improves mood. Accelerates falling asleep, reduces the number of nightly awakenings, improves health after a morning awakening, does not cause a feeling of lethargy, weakness and fatigue upon awakening. Makes dreams more vivid and emotionally intense. Adapts the body to the rapid change of time zones, reduces stress reactions, regulates neuroendocrine functions. Shows immunostimulating and antioxidant properties. Inhibits the secretion of gonadotropins, to a lesser extent - others.hormones adenohypophysis - corticotropin, TSH, GH. Melatonin secretion is subject to the circadian rhythm, which determines the rhythm of gonadotropic effects and sexual function. Synthesis and secretion of melatonin depend on the illumination - an excess of light inhibits its formation, the decrease in illumination increases the synthesis and secretion of the hormone. In humans, 70% of the daily production of melatonin accounts for night hours. Under the influence of melatonin, the content of the inhibitory mediator GABA increases in the CNS and serotonin in the midbrain and hypothalamus.

Indications and usage

Disruption of the normal circadian rhythm (desynchronosis) (due to the rapid movement between the time zones of the Earth); fatigue, sleep disturbances (including in elderly patients); depressive syndrome.

Contraindications

Hypersensitivity, allergic diseases, autoimmune diseases, Hodgkin's disease, leukemia, lymphoma, myeloma, epilepsy, diabetes mellitus, chronic renal failure, pregnancy, lactation.

Dosage and administration

Circadin is taken orally, 1.5-3 mg 1 time per day, 30-40 minutes before bedtime. The maximum daily dose is 6 mg.

Adverse reactions

Allergic reactions, headache, nausea, vomiting, diarrhea, morning drowsiness, swelling.

Special notes

It is necessary to inform women who want to become pregnant about the presence of a weak contraceptive effect. Avoid bright light. During the period of treatment, care must be taken when driving and occupying others.potentially hazardous activities that require increased concentration of attention and quickness of psychomotor reactions.

Drug Interactions

Incompatible with MAO inhibitors, corticosteroids, cyclosporine. Enhances the effect of (mutually) drugs that depress the central nervous system, and beta-blockers. Not recommended simultaneous reception with NSAIDs.

Storage conditions

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.