Cuprenil pills 250mg №100

/Cuprenyl

Active ingredient and dosage form

Kuprenil - coated tablets: 1 table. contains d-penicillamine 250 mg, excipients: potato starch; PVP; talc; Magnesium stearate; hydroxymethylpropylcellulose; polyoxyethylene glycol; titanium dioxide; a dye (E122); in packing of 30 and 100 pieces.

butcologic action

Kuprenil has a complexing, immunosuppressive, inhibiting collagen synthesis action.

Indications and usage

Wilson-Konovalov disease, intoxication with copper, mercury, lead, gold. Cystine nephrolithiasis, hemosiderosis, rheumatoid arthritis, scleroderma, alcoholic cirrhosis of the liver with hepatomegaly, fibroplastic variant of glomerulonephritis.

Contraindications

Hypersensitivity, agranulocytosis, systemic lupus erythematosus, myasthenia, renal failure, pregnancy, breastfeeding.

Adverse reactions

On the part of the digestive system: anorexia, nausea, vomiting, diarrhea, aphthous stomatitis, glossitis, intrahepatic cholestasis, pancreatitis.

On the part of the hematopoietic system: eosinophilia, thrombocytopenia, leukopenia, anemia (aplastic or hemolytic), agranulocytosis.

On the part of the respiratory system: interstitial pneumonitis, diffuse fibrosing alveolitis, Goodpasture syndrome.

From the side of the central nervous system and peripheral nervous system: complete loss or distortion of taste sensations; rarely reversible polyneuritis (associated with vitamin B6 deficiency).

Dermatological reactions: skin rash, epidermal necrolysis, alopecia.

Allergic reactions: allergic alveolitis, fever, polymyositis, dermatomyositis, lupus-like reactions (arthralgia, myalgia, erythematous rash, appearance of antinuclear antibodies and antibodies to DNA).

Other: nephritis, an increase in the mammary glands with the development of galactorrhea (in women), myasthenia.

Dosage and administration

Kuprenil is taken orally, 1-2 hours before a meal or 2 hours after a meal or other drugs. To wash down exclusively with water.

In Wilson's disease - Konovalov: adults - at the beginning of treatment 250 mg / day, gradually increasing the dose to 1500 mg, rarely up to 2000 mg / day. The daily dose is taken fractionally during the day. The dose of Cuprenil is considered effective if the daily excretion of copper in the urine (after 1 week of treatment) exceeds 2 mg. In the future, the adequacy of the dose is determined on the basis of the level of free copper in the serum (not less than 10 μg / ml). Children - 20 mg / kg / day, the maximum daily dose - 500 mg.

In acute metal poisoning: adults - 750-1500 mg / day, children - 30-40 mg / kg / day.

When cystinuria: adults - 750-2000 mg / day with the simultaneous appointment of vitamin B6 and compensation for copper deficiency, children - 90 mg / kg / day.

In rheumatoid arthritis and scleroderma: the initial dose of Cuprenil is 125 mg / day for the first week with regular general blood and urine tests.From the second week, the dose is increased to 250 mg / day, from the third to 375 mg / day. Treatment with the last dose (375 mg / day) is carried out every day for 3 months. The maximum dose of Cuprenil is 500 mg / day; if it is ineffective, treatment is canceled. With the improvement of the condition, the treatment is continued for 1-2 years, gradually reducing the dose to 250 mg, taken 1 time in 2 days.

With alcoholic cirrhosis of the liver: on an empty stomach, no less than 1 hour before or 2 hours after a meal (recommended before dinner), and not earlier than 1 hour after taking any other drugs, 250-125 mg once a day. Therapy is carried out under careful control of the activity of ALT and AST in the blood plasma.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C. Shelf life - 3 years.