Cerepro 400mg capsules №28
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Capsules soft gelatinous, from red to brown color, oblong; the contents of the capsules are oily, clear, colorless or slightly colored liquid.
1 caps (glycerylphosphorylcholine hydrate) 400 mg
Excipients:glycerol (glycerin), purified water.
The composition of the shell of the capsule: medical gelatin, glycerol (glycerin), methyl parahydroxybenzoate (methyl paraben), propyl parahydroxybenzoate (propyl paraben), iron dye red oxide, titanium dioxide, purified water, sorbitol (sorbitol).
Mechanism of action
Cholinomimetic central action, which contains 40.5% of metabolically protected choline (metabolic protection contributes to the release of choline in the brain). When ingested, it is broken down by the action of enzymes on choline and glycerophosphate: choline is involved in the biosynthesis of acetylcholine, one of the main mediators of nervous excitation; glycerophosphate is a precursor of phospholipids (phosphatidylcholine) of the neuronal membrane. The drug provides the synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation; increases linear blood flow velocity on the side of traumatic brain damage,contributes to the normalization of the spatial-temporal characteristics of the spontaneous bioelectric activity of the brain; It has a positive effect on the cognitive and behavioral reactions of patients with vascular diseases of the brain.
The drug improves brain function by acting on the pathogenetic factors of involutional psychoorganic syndrome, changes the phospholipid composition of neuronal membranes and reduces cholinergic activity. Dose-dependent stimulates the release of acetylcholine, participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission, plasticity of neuronal membranes, the function of receptors.
- acute and recovery periods of severe traumatic brain injury and ischemic, recovery period of hemorrhagic stroke, occurring with focal hemispheric symptoms or symptoms of a brain stem lesion;
- psychoorganic syndrome on the background of degenerative and involutional changes in the brain;
- cognitive disorders (impaired mental function, memory, confusion, disorientation, reduced motivation, initiative and ability to concentrate), including with dementia and;
- senile pseudomelancholia.
- lactation period (breastfeeding);
- hypersensitivity to the drug.
Gastrointestinal: nausea (as a consequence of dopaminergic activation).
Other: allergic reactions.
Drug interaction of the drug is not installed.
How to take, the course of administration and dosage
Atacute conditions the drug is administered intramuscularly or intravenously (slowly) at a daily dose of 1 g (1 ampoule) for 10-15 days, then transferred to the oral administration of the drug at a daily dose of 1.2 g (800 mg / 2 caps / morning) and 400 mg / 1 caps / day) for 6 months.
Atchronic conditions the drug is administered orally at 400 mg (1 capsule.) 3 times / day. The duration of therapy is 3-6 months.
Capsules are recommended to take before meals.
Treatment: gastric lavage, reception of Activated carbon, symptomatic therapy.
in a dry, protected from light and inaccessible to children place at a temperature of 25 ° C.