Wobenzym pills №800

Composition

1 enteric coated pill contains:
Core:

Active ingredients:

Pancreatin 300 Prot. Unit (100.0 mg), papain 90 FIP (18.00 mg), rutoside trihydrate 50.00 mg, bromelain 225 FIP Ed. (45.00 mg), trypsin 360 FIP Unit. (12.00 mg), lipase 34 FIP (10.00 mg), amylase 50 FIP Unit. (10,00 mg), chymotrypsin 300 FIP Unit. (0.75 mg).

Excipients:

Lactose monohydrate, 149 mg, starch, pregelatinized, 31.3 mg, Magnesium stearate, 6.00 mg, stearic acid, 6.00 mg, silica, anhydrous colloidal silica, 3.00 mg, talc, 1.50 mg.

Shell:

Film shell 11.9 mg (methacrylic acid-methyl methacrylate copolymer (1: 1) 11.9 mg, sodium lauryl sulfate 0.04 mg), talc 4.23 mg, macrogol 6000 0.67 mg, triethyl citrate 1.20 mg, stearic acid 6.00 mg, color coating 12.8 mg (hypromellose 3.20 mg, hydroxypropylcellulose 3.83 mg, microcrystalline cellulose 1.60 mg, glycerol 0.64 mg, talc 1.92 mg, titanium dioxide 0.38 mg, the dye crimson 4R (E 124) 0.38 mg, the dye yellow-orange S (E 110) 0.83 mg).

Description

round, biconvex pills with a smooth surface, from red-orange to red in color, with a characteristic odor.

Pharmacotherapeutic group:

anti-inflammatory, immunomodulatory agent.

Pharmacological properties

VOBANZIM is a combination of natural enzymes of plant and animal origin.Entering the body, the enzymes are absorbed in the small intestine by resorption of intact molecules and, by binding to the transport proteins of the blood, enter the bloodstream. In the future, the enzymes, migrating along the vascular bed and accumulating in the zone of the pathological process, have immunomodulatory, anti-inflammatory, fibrinolytic, anti-edema, antiplatelet and secondary analgesic effect.
VOBENZIM has a positive effect on the course of the inflammatory process, limits the pathological manifestations of autoimmune and immunocomplex processes, has a positive effect on the immunological reactivity of the organism. It stimulates and regulates the level of functional activity of monocyte macrophages, natural killer cells, stimulates antitumor immunity, cytotoxic T-lymphocytes, phagocytic activity of cells.
Under the influence of VOBENZIMA, the number of circulating immune complexes decreases and membrane deposits of immune complexes are removed from the tissues.
VOBENZIM reduces the interstitial infiltration of plasma cells. Increases the elimination of protein debris and fibrin deposits in the area of ​​inflammation, accelerates the lysis of toxic metabolic products and necrotic tissue. VOBANZIM normalizes the permeability of the walls of blood vessels, contributes to a more rapid resorption of hematomas and edema.
VOBENZIM reduces the concentration of thromboxane and platelet aggregation.It regulates adhesion of blood cells, increases the ability of red blood cells to change their shape, adjusting their plasticity, normalizes the number of normal discocytes and reduces the total number of activated platelet forms, normalizes blood viscosity, reduces the total number of microaggregates, thus improving the microcirculation and rheological properties of blood, as well as supplying tissues oxygen and nutrients.
VOBENZIM reduces the severity of side effects associated with hormonal drugs (hypercoagulation, etc.).
VOBANZIM normalizes lipid metabolism, reduces the synthesis of endogenous cholesterol, increases the content of high-density lipoproteins, reduces the level of atherogenic lipids, improves the absorption of polyunsaturated fatty acids.
VOBENZIM increases the concentration of antibiotics in the blood plasma and inflammation, thus increasing the effectiveness of their use. At the same time, enzymes reduce undesirable side effects of antibiotic therapy (dysbacteriosis) by improving the environment.
VOBANZIM regulates the mechanisms of nonspecific protection (production of interferons), thereby showing antiviral and antimicrobial action.

Indications for use

It is used in the treatment of the following diseases:

Angiology:thrombophlebitis, treatment of postthrombophlebitic disease and acute thrombophlebitis of the superficial veins, endarteritis and atherosclerosis obliterans of lower limb arteries, prevention of recurrent phlebitis,lymphatic edema.
Urology:cystitis, cystopielitis, prostatitis, sexually transmitted infections.
Gynecology:chronic infections of the genitals, adnexitis, gestosis, mastopathy, to reduce the frequency and severity of side effects of hormone replacement therapy.
Cardiology:angina pectoris, subacute stage of myocardial infarction (to improve the rheological properties of blood).
Pulmonology:sinusitis, bronchitis, pneumonia.
Gastroenterology:pancreatitis, hepatitis.
Nephrology:pyelonephritis, glomerulonephritis.
Endocrinology:diabetic angiopathy, diabetic retinopathy, autoimmune thyroiditis.
Rheumatology:rheumatoid arthritis, reactive arthritis, ankylosing spondylitis.
Dermatology:atopic dermatitis, acne.
Surgery:prevention and treatment of postoperative complications (inflammation, thrombosis, edema), adhesive disease, post-traumatic and lymphatic edema, plastic and reconstructive surgery.
Traumatology:injuries, fractures, distortion, damage to the ligaments, bruises, chronic post-traumatic processes, soft tissue inflammation, burns, injuries in sports medicine.
Neurology:multiple sclerosis.
Pediatrics:atopic dermatitis, infectious and inflammatory diseases of the respiratory tract (inflammation of the upper and lower respiratory tract, pneumonia), juvenile rheumatoid arthritis, prevention and treatment of postoperative complications (suppuration and poor wound healing, formation of adhesions,local swelling).
Ophthalmology:uveitis, iridocyclitis, hemophthalmus, diabetic retinopathy, ophthalmosurgery.
Prevention:microcirculation disorders, post-stress disorders, as well as the breakdown of adaptation mechanisms. Prevention of side effects of hormone replacement therapy, hormonal contraception. In surgical interventions to prevent infectious complications and adhesive disease.

VOBENZIM is recommended for the prevention of infectious complications and improving the quality of life during Chemotherapy or radiotherapy. Prevention of viral infections and their complications.

Contraindications

Individual intolerance to the drug. Diseases associated with an increased likelihood of bleeding (hemophilia, thrombocytopenia, etc.). Hemodialysis. Children's age up to 5 years.

Use during pregnancy and during breastfeeding

Pregnancy and breastfeeding are not a contraindication to the use of the drug, however, pregnant women should take VOBENZIM under the supervision of a physician.

Dosage and administration

Tablets should be taken orally, at least 30 minutes before a meal, without chewing, drinking water (200 ml).

Adults

Depending on the activity and severity of the disease, VOBENZIM is taken in a dose of from 3 to 10 pills 3 times a day. In the first three days of taking the drug, the recommended dose is 3 pills 3 times a day.
With an average disease activity, VOBENZIM is prescribed in a dose of 5-7 pills 3 times a day for 2 weeks. In the future, the dose of VOBENZIMA should be reduced to 3-5 pills 3 times a day, a course of 2 weeks.
With high disease activity VOBENZIM prescribed in a dose of 7-10 pills 3 times a day for 2-3 weeks. Further, the dose of VOBENZIMA is reduced to 5 pills 3 times a day, a course of 2-3 months.
In case of chronic long-term current diseases, VOBENZIM can be used according to indications in courses from 3 to 6 months or more.
In order to increase the effectiveness of antibiotics and the prevention of dysbacteriosis, VOBENSIM should be used throughout the entire course of antibiotic therapy in a dose of 5 pills 3 times a day. After stopping the course of antibiotics to restore the microflora (biocenosis) of the intestine, VOBENZIM should be prescribed 3 pills 3 times a day for 2 weeks.
As a “cover” therapy during chemotherapy and radiation therapy, VOBENZIM should be applied in a dose of 5 pills 3 times a day until completion of the course of chemotherapy and radiation therapy; to prevent infectious complications, improve the tolerability of basic therapy and improve the quality of life.
When using VOBENZIMA with prophylactic treatment, the dose of the drug is 3 pills 3 times a day, a course of 1.5 months, repeated 2-3 times a year.

Children

Children from 5 to 12 years old - 6 kg of weight of the child 1 pill per day. From 12 years old according to the scheme for adults. Dosage and duration of treatment depend on the severity of the disease and are determined by the doctor.

Side effect

VOBENZIM well tolerated by patients.In most cases, side effects, withdrawal syndrome, addiction was not observed even with prolonged treatment with high doses. In some cases, there are minor changes in the consistency and smell of feces, skin rash in the form of urticaria, which take place with a decrease in the dose of the drug or cancellation.
If there are other adverse reactions that are not noted in the instructions, it is recommended to stop taking the drug and consult a doctor.

Overdose

Cases of overdose of the drug is unknown.

Interaction with other drugs

While taking VOBANZIMA with other drugs incompatibility cases are not described.

special instructions

In the case of infectious processes, VOBENZIM does not replace antibiotics, but increases their effectiveness by increasing the concentration in the blood plasma and the focus of inflammation.
It should be borne in mind that at the very beginning of the drug, the symptoms of the disease may worsen, in such cases, treatment should not be interrupted, and a temporary reduction in the dose of the drug is recommended. The drug is not doping.

Influence on ability to steer vehicles, mechanisms

The drug does not adversely affect the ability to drive vehicles and perform work that requires a high rate of mental and physical reactions.

800 pills per vial of high density polyethylene. On 1 bottle together with the application instruction in a pack cardboard.

Storage conditions

At temperatures not above 25 ° C.
Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Vacation conditions

Let go without a prescription.