

- Dementia of moderate and severe severity in Alzheimer's disease.
The drug Akatinol memantine should be taken orally 1 time / day and always at the same time. Can be taken regardless of the meal.
- 1st week (days 1-7): 1 pill with a dosage of 5 mg every day for seven days;
- 2nd week (days 8-14): 1 pill with a dosage of 10 mg every day for seven days;
- 3rd week (days 15-21): 1 pill with a dosage of 15 mg every day for seven days.
Starting from the 4th week: one pill of Akatinol memantine with a dosage of 20 mg each day.
Adverse reactions are classified by clinical manifestations (according to the lesion of certain organ systems) and by frequency of occurrence: very often (> 1/10), often (> 1/100 to <1/10), infrequently (> 1/1000 to < 1/100), rarely (> 1/10000 to <1/1000), very rarely (<1/10000), the frequency has not been established (currently there are no data on the prevalence of adverse reactions).
On the part of the body as a whole - common adverse reactions | Often | Headache |
The immune system | Often | Hypersensitivity to the components of the drug |
Infections | Seldom | Fungal infections |
Mental disorders | Often | Drowsiness |
Violations of the cardiovascular system | Often | Increased blood pressure |
Respiratory system | Often | Shortness of breath |
Gastrointestinal disturbances | Often | Constipation Pancreatitis |
Disturbances from the central and peripheral nervous system | Often | Dizziness |
* hallucinations were observed mainly in patients with Alzheimer's disease at the stage of severe dementia.
There are separate reports of the occurrence of these adverse reactions when using the drug Akatinol memantine in clinical practice (data obtained after the appearance of the drug on the market): dizziness, drowsiness, anxiety, fatigue, anxiety, increased intracranial pressure, nausea, hallucinations, headache, disturbance of consciousness, muscle hypertonus, gait disturbances, depression, convulsions, psychotic reactions, suicidal thoughts, constipation, nausea, pancreatitis, candidiasis, increased arterial pressure, vomiting, cystitis, increased libido, venous thrombosis, thromboembolism, allergic reactions.
- hypersensitivity to the drug Akatinol memantine;
- severe renal failure (CC 5-29 ml / min);
- severe liver failure;
- pregnancy;
- breastfeeding period;
- age up to 18 years. (Due to insufficient data).
with caution prescribe the drug Akatinol memantine for patients with thyrotoxicosis, epilepsy; predisposition to the development of seizures, simultaneous use of NMDA receptor antagonists (amantadine, ketamine, dextromethorphan), the presence of factors that increase urine pH (abrupt diet change, for example, switching to vegetarianism, abundant intake of alkaline buffer solutions), severe urinary tract infections (caused by Proteus bacteria), myocardial infarction (in history), heart failure III-IV functional class (according to NYHA classification), uncontrolled arterial hypertension, renal failure, hepatic failure.