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Delagil - antiprotozoal agent, also has an immunosuppressive and anti-inflammatory effect. Causes the death of asexual erythrocyte forms of all types of plasmodia. It has a gametocidal effect, with the exception of Plasmodium falciparum (exhibits anti-gametocidal action). Due to inhibition of the synthesis of nucleic acids, it has a moderately pronounced immunosuppressive and nonspecific anti-inflammatory effect.
Malaria (prevention and treatment of all types), extraintestinal amebiasis, amebic liver abscess, SLE (chronic and subacute forms), rheumatoid arthritis, scleroderma, photodermatosis, late skin porphyria.
Hypersensitivity, hepatic and / or renal failure, inhibition of bone marrow hematopoiesis, severe rhythm disturbances, psoriatic arthritis, neutropenia, porphyrinuria, pregnancy. With caution. Deficiency of glucose-6-phosphate dehydrogenase, retinopathy, epilepsy.
Delagil take inside. For the prevention of malaria: 500 mg in the first week, 2 times, then 1 time on the same day of the week.Malaria treatment is carried out according to the following scheme: 1st day - once 1 g, after 6–8 h - 500 mg; on the 2nd and 3rd day of treatment - 750 mg daily in one session. In amebiasis: 500 mg 3 times a day for 7 days, then 250 mg 3 times a day for another 7 days, then 750 mg 2 times a week for 2-6 months. In rheumatoid arthritis: 250 mg 2 times a day for 7 days, then 250 mg daily for 12 months. With systemic lupus erythematosus: 250–500 mg daily. With photodermatosis: 250 mg daily for 1 week, then 500-750 mg weekly.
On the part of the digestive system: nausea, vomiting, gastralgia. Nervous system disorders: dizziness, headache, sleep disturbances, psychosis, seizures. On the part of the cardiovascular system: myocardial damage with changes on the ECG, lowering blood pressure. On the part of the senses: with prolonged use - corneal clouding, retinal damage, blurred vision, tinnitus. Allergic reactions: dermatitis, photosensitivity. Other: myalgia, leukopenia, discoloration of the skin and hair.
During the period of treatment, it is necessary to conduct systematic examinations of an oculist and general blood tests.
Symptoms: vomiting, impaired consciousness, visual disturbance, convulsions, collapse, depression of the respiratory center, even death (within 2 hours from the moment of respiratory depression).
Treatment: gastric lavage, ingestion of Activated carbon at a dose of 5 times the estimated dose of chloroquine; challenge vomiting, peritoneal dialysis, plasmapheresis.
At temperatures not above 25 ° C.