Azitrox capsules 250mg №6

Pharmacology

- broad-spectrum antibiotic. It is the first representative of a new subgroup of macrolide antibiotics - azalides. When creating in the focus of inflammation of high concentrations has a bactericidal effect.
Gram-positive cocci are sensitive to Azithromycin : Streptococcus pneumoniae, St. pyogenes, St. agalactiae, streptococcus groups CF and G, Staphylococcus aureus, St. Viridans; Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, B. parapertussis, Legionella pneumophila, H. ducrei, Campylobacter jejuni, Neisseria gonorrhoeae and Gardnerella vaginalis; some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp; as well as Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. Azithromycin is inactive against gram-positive bacteria that are resistant to Erythromycin.

Azithromycin remains in bactericidal concentrations in the inflammatory focus for 5–7 days after the last dose, which allowed the development of short (3-day and 5-day) courses of treatment.

Indications and usage

- Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- Infections of the upper respiratory tract and ENT organs (tonsillitis, sinusitis, tonsillitis, otitis media);
- Scarlet fever
- Infections of the lower respiratory tract (bacterial and atypical pneumonia, bronchitis);
- Infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatosis);
- Infections of the urogenital tract (uncomplicated urethritis and / or cervitis);
- Lyme disease (borreliosis), for the treatment of the initial stage (erithema migrans);
- Disease of the stomach and duodenum associated with Helicobacter pylori /

Azitrox^® be sure to take 1 hour before meals or 2 hours after meals. The drug is taken 1 time / day.
At infections of the upper and lower respiratory tract infections of the skin and soft tissues appoint 500 mg / day for 3 days (course dose - 1.5 g).
At uncomplicated urethritis and / or cervix administered once 1 g (4 caps. 250 mg each).
At Lyme disease (borreliosis) for the treatment of the initial stage (erithema migrans) is prescribed in 1 g (4 capsules. 250 mg) on ​​the 1st day and 500 mg daily from the 2nd to the 5th day (course dose - 3 g).
At diseases of the stomach and duodenum associated with HelicobacterPylori, designate 1 g (4 caps. 250 mg) per day for 3 days as part of combination therapy.
In case of missing a dose of the drug, the missed dose should be taken as early as possible, and the next ones - with a break of 24 hours.

Adverse reactions

From the gastrointestinal tract, liver: possible nausea diarrhea, abdominal pain; rarely - vomiting, flatulence, transient increase in liver enzymes.
Dermatological reactions: in some cases - a rash.

Contraindications

- Hypersensitivity to macrolide antibiotics;
- Severe dysfunction of the liver and kidneys;
- Pregnancy;
- Breastfeeding (at the time of treatment is suspended);
- Children under 12 years old

Drug interactions

It is recommended to observe a break of at least 2 hours between doses. Azitrox^® and antacid drugs.
Enhances the action of ergot alkaloids, dihydroergotamine; tetracyclines and chloramphenicol - action synergism; Lincosamides reduce efficacy. Antacids, ethanol food - slow down and reduce absorption. Cycloserine, indirect anticoagulants, methylprednisolone, felodipine coumarin anticoagulants - slowing excretion, increasing serum concentrations and increasing the toxicity of the listed drugs. Inhibiting microsomal oxidation and hepatocytes, lengthens the half-life, slows down the excretion, increases the concentration and toxicity of drugs (including Carbamazepine, ergot alkaloids, valproic acid, hexobarbital, phenytoin, disopyramide, Bromocriptine, theophyline, and I can not use the object and I’m not already using the therapist for a new method to get the same). ).

Pharmaceutical incompatible with Heparin.

List B. In a dry, the dark place at room temperature. Keep out of the reach of children.