Suprax Solutab pills dispersible 400mg №7

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

- Streptococcal tonsillitis and pharyngitis;

- sinusitis;

- acute bronchitis;

- exacerbation of chronic bronchitis;

- acute otitis media;

- uncomplicated urinary tract infections;

- uncomplicated gonorrhea;

- shigellosis.

Dosage and administration

For adults and children weighing more than 50 kg The daily dose is 400 mg in 1 or 2 doses.

Children with a body weight of 25-50 kg The drug is prescribed at a dose of 200 mg / day in 1 reception.

The pill can be swallowed with a sufficient amount of water, or diluted in water and drink the resulting suspension immediately after preparation. The drug can be taken regardless of the meal.

The duration of treatment depends on the nature of the course of the disease and the type of infection. After the disappearance of symptoms of infection and / or fever, it is advisable to continue taking the drug for at least 48-72 hours.

The course of treatment for respiratory infections and upper respiratory tract infections makes 7-14 days.

At tonsillopharyngitis caused by Streptococcus pyogenesThe duration of treatment must be at least 10 days.

At uncomplicated gonorrhea the drug is prescribed in a dose of 400 mg once.

At uncomplicated infections of the lower urinary tract in women the drug is prescribed for 3-7 days, with uncomplicated infections of the upper urinary tract in women - within 14 days.

At uncomplicated infections of the upper and lower urinary tract in men the duration of treatment is 7-14 days.

At renal dysfunction the dose is set depending on the CC in the serum. At CC 21-60 ml / min or at hemodialysis patientsIt is recommended to use other dosage forms of the drug due to the need to reduce the daily dose by 25%. At QC 20 ml / min and less or at peritoneal dialysis patients, the daily dose should be reduced by 2 times.

Adverse effects

Side effects are classified according to the frequency of reported cases: very often (> 10%); often (1-10%); infrequently (0.1-1%); rarely (0.01-0.1%); very rarely (≤ 0.01%).

Hemic and lymphatic: very rarely, transient leukopenia, agranulocytosis, pancytopenia, thrombocytopenia, or eosinophilia; in some cases - a violation of blood coagulation.

Allergic reactions: rarely - urticaria, pruritus; very rarely - Lyell's syndrome (in this case, the drug should be immediately canceled), drug fever, serum sickness syndrome, hemolytic anemia and interstitial nephritis (epinephrine (adrenaline), systemic GCS and antihistamines are administered during the development of anaphylactic shock).

From the side of the central nervous system: infrequently - headaches, dizziness, dysphoria.

From the digestive system: often - abdominal pain, digestive disorders, nausea, vomiting and diarrhea; rarely, transient increases in alkaline phosphatase and transaminase levels; very rarely - pseudomembranous colitis; in some cases - hepatitis and cholestatic jaundice.

Urogenital: very rarely - a slight increase in the concentration of creatinine in the blood, hematuria.

Contraindications

- Hypersensitivity to cephalosporins or penicillins;

- Hypersensitivity to cefixime or components of the drug.

Not recommended for use in children with chronic renal failure and in children weighing less than 25 kg in this dosage form.

WITH caution the drug should be prescribed for renal failure, colitis (in history), during pregnancy, as well as for elderly patients.

Use during pregnancy and lactation

The use of the drug Ceforal Solutab during pregnancy is possible in the case when the intended benefit to the mother outweighs the potential risk to the fetus.

If necessary, the use of the drug during lactation breastfeeding should be temporarily discontinued.

Application for violations of kidney function

WITH caution It should appoint a drug for renal failure. At renal dysfunction the dose is set depending on the CC in the serum. At CC 21-60 ml / min or at hemodialysis patientsIt is recommended to use other dosage forms of the drug due to the need to reduce the daily dose by 25%. At QC 20 ml / min and less or at peritoneal dialysis patients, the daily dose should be reduced by 2 times.

Not recommended for use in children with chronic renal failure.

Use in children

Not recommended for use in children with chronic renal failure and in children weighing less than 25 kg in this dosage form.

Use in elderly patients

WITH caution the drug should be prescribed to elderly patients.

Special notes

Due to the possibility of cross-allergic reactions with penicillins, it is recommended to carefully evaluate the history of patients. In the event of an allergic reaction, the use of the drug should be immediately discontinued.

With long-term use of the drug may disrupt the normal intestinal microflora, which can lead to excessive reproduction of Clostridium difficile and the development of pseudomembranous colitis. When mild forms of antibiotic-associated diarrhea appear, it is usually enough to stop taking the drug. In more severe forms, corrective treatment is recommended (for example, oral administration of Vancomycin 250 mg 4 times / day). Antidiarrheal drugs that inhibit gastrointestinal motility, with the development of pseudomembranous colitis are contraindicated.

In the case of the use of the drug Ceforal Solutab simultaneously with aminoglycosides, polymyxin B, sodium colysymetatum, "loop" diuretics (furosemide, ethacrynic acid) in high doses, it is necessary to monitor the kidney function very carefully.After long-term treatment with Ceforal Solutab, the state of hematopoiesis function should be checked.

Dispersible pills should be dissolved only in water.

During treatment, a false-positive direct Coombs reaction and a false-positive reaction of urine to glucose are possible when using some test systems for rapid diagnosis.

Influence on ability to drive motor transport and control mechanisms

Studies on the effects of the drug Ceforal Solutab on the ability to drive vehicles and mechanisms were not conducted. Due to possible adverse effects (eg, dizziness), caution should be exercised.

Overdosage

When taken in a dose exceeding the maximum daily, it is possible to increase the frequency of the above dose-dependent side effects.

Treatment: gastric lavage; conduct symptomatic and supportive therapy. Hemodialysis and peritoneal dialysis are not effective.

Drug interaction

Tubular secretion blockers (including probenecid) slow down the excretion of cefixime in the urine, which can lead to overdose symptoms.

Cefixime reduces the prothrombin index, enhances the effect of indirect anticoagulants.

With simultaneous use of cefixime with Carbamazepine, an increase in plasma concentration of the latter was observed; in such cases it is advisable to conduct therapeutic drug monitoring.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.