Invega 3mg pills №28

Packaging

28 pcs.

Mechanism of action

Invega- antipsychotic agent (neuroleptic)
Paliperidone is a centrally acting dopamine antagonist D₂ receptors, which also has high antagonism against serotonin 5-HT₂ -receptors. In addition, paliperidone is an alpha antagonist.₁- and alpha₂-adrenergic receptors and H₁- histamine receptors.

Overdosage

The objective and subjective symptoms of paliperidone overdose are enhanced pharmacological effects of this drug, i.e. drowsiness, sedation, tachycardia, hypotension, prolongation of the QT interval, extrapyramidal symptoms.There is no specific antidote for paliperidone. It is necessary to implement generally accepted supporting measures. Interaction with other drugs

Caution should be exercised while the appointment of paliperidone with drugs that extend the QT interval. Paliperidone is not a substrate of isoenzymes of the cytochrome P450 system, which indicates a low probability of its interaction with inhibitors and inductors of these enzymes. Paliperidone does not cause significant inhibition of biotransformation of drugs that are metabolized by isoenzymes of cytochrome P450. Given that paliperidone acts primarily in the central nervous system, it must be used with caution in combination with other drugs of central action and alcohol. In vitro studies have shown that paliperidone is a substrate of P-glycoprotein. When combined use of paliperidone with Carbamazepine, which is an inducer of renal P-glycoprotein, you may need to increase the dose of paliperidone. special instructions

It is known that antipsychotic drugs, including paliperidone, can cause neuroleptic malignant syndrome, tardive dyskinesia, lengthening of the QT interval, dysregulation of body temperature. Drugs with the activity of alpha-blockers, including paliperidone, can cause orthostatic hypotension, priapism. In clinical studies of paliperidone, hyperglycemia and its undesirable effects have been rarely observed. In preclinical studies, the antiemetic effect of paliperidone was identified.Impact on driving and working with machinery

Paliperidone may interfere with activities that require a quick mental reaction, and may also have visual effects, so patients should refrain from driving a car or working with mechanisms until their individual sensitivity to paliperidone is established. Shelf life: 2 years Storage conditions: Store at a temperature of 15 to 30 ° C out of the reach of children.