Chorionic gonadotropin 500ed ampoule №5 + solvent

Hormonal drug secreted from the urine of pregnant women. It has luteinizing, follicle-stimulating, gonadotropic, estrogenic and progestogenic effects. Stimulates the synthesis of sex hormones in the ovaries and testicles, ovulation, spermatogenesis, provides the function of the corpus luteum; stimulates the development of sexual organs and secondary sexual characteristics.

Indications and usage

Hypofunction of the genital glands (due to impaired activity of the hypothalamus and pituitary gland). In women: dysmenorrhea, ovarian dysfunction, anovulatory infertility, insufficiency of the corpus luteum (in the presence of estrogenic function of the ovaries), "superstimulation" during assisted reproductive techniques, habitual miscarriage, threatening spontaneous miscarriage. In men: genetic disorders: hypogenitalism, eunuchoidism; testicular hypoplasia, cryptorchism; adiposogenital syndrome, hypophysial nanism, sexual infantilism; oligoasthenospermia, azoospermia.

Contraindications

Hypersensitivity, ovarian cancer, pituitary tumor; androgen-dependent tumors; hypothyroidism, adrenal insufficiency, hyperprolactinemia; gonadal dysgenesis, early onset of menopause, obstruction of the fallopian tubes, thrombophlebitis, lactation.With care - adolescence, ischemic heart disease, arterial hypertension, chronic renal failure, bronchial asthma, migraine.

V / m Women for the induction of ovulation - simultaneously 5000-10000 IU, to stimulate the function of the corpus luteum - 1500-5000 IU for 3-6-9 days after ovulation. For the implementation of "superovulation" in the course of assisted reproductive measures - up to 10,000 IU once after the induction of growth of multiple follicles, which is achieved as a result of stimulation according to an established scheme. Egg collection takes place 34-36 h after injection. With habitual miscarriage - the introduction begins immediately after pregnancy is diagnosed (but no later than 8 weeks) and continues until 14 weeks of pregnancy, inclusive: 10,000 IU on 1 day, then 5,000 IU 2 times a week. With the threat of spontaneous miscarriage (if the symptoms appeared in the first 8 weeks of pregnancy) - 10,000 IU initially, then 5,000 IU 2 times a week to 14 weeks of pregnancy, inclusive. With delayed sexual development of boys - 3000-5000 IU once a week for at least 3 months. For men - 500-2000 IU once a day, 2-3 times a week, for 1.5-3 months. When hypogonadotropic hypogonadism - 1500-6000 IU (in combination with menotropin) 1 time per week. For the purpose of differential diagnosis of cryptorchidism and hypogonadotropic hypogonadism - once, 5000 IU. When cryptorchidism: at the age of 6 years - 500-1000 IU 2 times a week for 6 weeks; over 6 years old - 1500 IU 2 times a week for 6 weeks. When idiopathic normogonadotropic oligospermia - 5000 IU weekly for 3 months together with menotropin.For oligospermia and asthenospermia caused by relative androgen deficiency - 2500 IU every 5 days or 10,000 IU once every 2 weeks for 3 months.

Adverse reactions

Local reactions (pain at the injection site, hyperemia), headache, fatigue, irritability, anxiety, depression; allergic reactions; suppression of gonadotropic pituitary function. In women, with the combined treatment of infertility (in combination with menotropin or clomiphene) - ovarian hyperstimulation syndrome (ovarian cyst with the danger of their rupture, the appearance of fluid in the abdominal and chest cavities). In men, fluid retention, edema, hypersensitivity of the nipples of the mammary glands, gynecomastia, an increase in the testicles in the inguinal canal (with cryptorchidism).

In men, it is ineffective at high levels of FSH. Prolonged administration can lead to the formation of antibodies to the drug. Increases the likelihood of multiple pregnancies. Erroneous results are possible when applying a test to determine pregnancy during drug treatment and within 7 days after withdrawal.